Joklik joined the microbiology department headed by
Frank Fenner at the then-new
Australian National University in
Canberra in 1953 and remained there for nine years, working primarily on
poxviruses. In 1959-60 he spent a year on
sabbatical at the
National Institutes of Health working with
Harry Eagle, who subsequently relocated to the
Albert Einstein College of Medicine in
New York City and recruited Joklik to join him there in 1962. Joklik's research group there continued to work on poxviruses as well as
vaccinia viruses and
reoviruses. In 1968 Joklik moved to
Duke University to chair the Department of Microbiology and Immunology, which he played a major role in developing from a small faculty of six to a large and nationally ranked department as of his retirement in 1993. Following the announcement of a "
war on cancer" by President
Richard Nixon in 1971, Joklik co-founded the
Duke Comprehensive Cancer Center.
Smallpox eradication Joklik's research on
vaccinia viruses led to his selection as one of two United States representatives to the
World Health Organization's
Smallpox Eradication Committee in the 1970s, whose efforts came to a close in 1980 when natural smallpox infections were declared to be eradicated and research stocks retained only by the United States
Centers for Disease Control and the
State Research Center of Virology and Biotechnology VECTOR in the then-
Soviet Union. Joklik was a highly vocal opponent of efforts in the 1990s to destroy the remaining stocks, delivering talks and writing several papers on the topic. ==Legacy==