Wyoming Highway 212 begins at its southern end at
Interstate 25 (Exit 7) and travels east and north around Cheyenne to Wyoming Highway 219 (Old Yellowstone Highway) north of Cheyenne. Beginning at I-25, Wyoming Highway 212 runs concurrent with Business Loop I-25 and US 87 Business until an intersection with South Greeley Highway (
US 85). After that intersection, WYO 212 passes
Laramie County Community College and turns northward toward
Interstate 80. WYO 212 intersects Fox Farm Road (former
Wyoming Highway 221) at before heading north to an interchange with I-80. Between the Interstate 80 interchange and
US 30 (Lincolnway), Wyoming Highway 212 runs concurrent with Business Loop I-80. After intersecting US 30, WYO 212 heads north and intersects busy Dell Range Blvd. which is a busy commercial strip for shopping and stores. WYO 212 then heads north and west around Cheyenne, taking on the name Four Mile Road. In the
Ranchettes, at the intersection of Four Mile Road and
WYO 219 (Yellowstone Road), WYO 212 approaches its northern end. WYO 212 ends at Hynds Boulevard, in front of
I-25. == Major intersections ==