This gene encodes a member of the 5′-3′
exonuclease family. The encoded protein may be involved in replication-dependent
histone mRNA degradation, and interacts directly with the enhancer of
mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including
transcription,
translation,
homologous recombination,
meiosis,
telomere maintenance, and
microtubule assembly. Mutations in this gene are associated with
osteosarcoma, suggesting that the encoded protein may also play a role in
bone formation.
Alternative splicing results in multiple transcript variants. ==See also==