Neoplecostomus yapo has a single spine and 7 soft rays supporting its dorsal finwhile its
anal fin is supported by a single spine and 5 soft rays. The upper body is almost wholly covered in dermal platesapart from the area around the base of the dorsal fin and the tip of the snout. The underside of the headis naked excpet for a dermal plate located close to the gill opening which bears some odontodes. There is an thoracic shield on the otherwise naked abdomen formed by small dermal plates situated between the pectoral and pelvic fins. This catfish has thick, rounded lips with the lower lip covered in
papillae almost extending as far as the pectoral girdle. The
barbel in the
maxilla is short and joined with the lower lip, usually the tip is free. There is an unpaired dermal plate in front of the
adipose fin. This species can be distinguished from almost all the other species in its genus by having hypertrophied odontodes and obvious thickened skin along the side of the snout in mature males and from
N. selenae by the absence of hypertrophied odontodes and obvious thickened skin along the ridges in front of the eyes. This species has an elongated, falttened body shape and it reaches a
standard length of . ==Distribution and habitat==