The yellow-nosed cotton rat does not compete well with other species of cotton rats, such as the
white-eared cotton rat (
Sigmodon leucotis), and where their ranges overlap, it occupies thinly vegetated, rocky slopes with tussocks of grass. In Arizona, it is often found on open slopes among scattered
Emory oak,
Arizona oak,
alligator juniper,
yucca,
agave,
mimosa,
sugar sumac,
prickly pear, and
desert spoon. These plants often have long foliage growing at their bases, and the cotton rat uses these for cover. It shares its habitat with the
fulvous harvest mouse (
Reithrodontomys fulvescens) and
southern pocket gopher (
Thomomys umbrinus) and uses the burrows of the latter, as well as cavities under boulders. Where it is the only cotton rat in a locality, the yellow-nosed cotton rat inhabits grassy meadows and alluvial fans where the soil is deeper. In these habitats, it makes runs between the clumps of grass, but in sparsely vegetated areas, these runways are difficult to discern. It is primarily active during the day, moving fast along its runways so as to be exposed to
predation for as little time as possible. It feeds primarily on
blue grama grass (
Bouteloua gracilis), but also the green parts of other plants such as
muhly,
three-leaf groundsel,
gumweed, and
three-awn tangle-head, and less frequently on seeds and fruits. It cuts sections of grasses and forms small piles of grass blades on the surface and
caches further piles of dried foliage underground, often in the abandoned burrows of southern pocket gophers. ==Status==