In early 2011 it emerged that Yodsanan had started training in
mixed martial arts at
Evolve MMA in Singapore. On July 15, 2011, it was announced that Yodsanan had signed with
ONE Fighting Championship. This has led some journalists to suggest that Yodsanan will be the best boxer to ever switch from boxing to MMA. He won the fight via TKO in the second round after landing a stunning flying knee to the face of his opponent. On March 31, 2012, Yodsanan faced Jiang Long Yun at
ONE Fighting Championship: War of the Lions in his second MMA appearance, where he lost via first-round submission. He would take a hiatus from mixed martial arts before returning four years later on May 27, 2016, to defeat Khon Sichan at
ONE Championship: Kingdom of Champions. On March 11, 2017, Yodsanan faced Ramon Gonzalez at
ONE Championship: Warrior Kingdom, which saw him score a comeback victory via verbal submission. On December 9, 2017, he defeated Dodi Mardian by first-round, one-punch knockout at
ONE Championship: Warriors of the World. ==Professional boxing record==