While Father Stephen Raymond was the principal of
St Patrick's High School in Karachi, she enrolled. Her teaching career at this institution lasted 34 years until she retired. One of her former pupils praised her as "one of the most well-loved teachers and mentors" during a school reunion on the 150th anniversary of its inception on 18 October 2010. Another student, Roland de Souza, called her "one of the best professors" he had ever had. The Old Patricians (past students of the school) gave the Yolande Henderson Gold Medal to the highest student from the Cambridge "O" level section at the school's 150th-anniversary closing ceremony on 6 May 2011. The
Society of Pakistan English Language Teachers (SPELT) paid homage to Henderson on 12 October 2012, saying that "her pupils all over the world are better people because of her leadership."
The Express Tribune invited her to write a memorial to the late Bishop Anthony Theodore Lobo, a former administrator of St Patrick's High School, in March 2013. ==Death==