Critical response to the single was positive. For the week of 16 January 2007, the track was chosen as the Single of the Week on the US
iTunes Store as a free download.
Newsweek also chose the song as its Pick of the Week for 15 January of the same year.
Billboard found that the track—"in original form—could be no better"; however, it acknowledged that the Ghostface Killah remix added a "ferocious discordant sputter at the midsection."
People magazine called the track "instantly memorable." Prior to this, Winehouse had not seen any success in the US, as her debut album
Frank was not released there until November 2007. On the
Billboard Hot 100, "You Know I'm No Good" debuted at number 91 spot ahead of "
Rehab", which also debuted on the chart the same week. The single peaked on the
UK Singles Chart at number 18 for the week ending 14 January 2007 in an excellent week for Winehouse that saw
Back to Black achieve a new UK peak of number one, previous single "Rehab" return to the UK top 20, and
Frank re-enter the UK chart at number 62 more than three years after its first release. To date, the single, which spent a total of 11 consecutive weeks on the UK Singles Chart, has sold 53,272 copies in the UK. Winehouse performed the song at the
50th Annual Grammy Awards ceremony while in London, along with her hit single "Rehab". The performance was broadcast internationally via satellite. The song's performance on the awards ceremony subsequently led to an increase in digital downloads, notably on iTunes, where the song re-entered the Top Songs chart at number 55 in the United States. This resulted in a new peak for the song on the
Billboard Hot 100, of number 77, one spot ahead of its previous peak.
Arctic Monkeys performed a cover of the song on their 2007 tour. A remix by Ghostface Killah appears on the reissue of
Back to Black, featuring one verse by Ghostface, and a second remix, featuring more Ghostface verses, appears on his album
More Fish. English actor
Roger Moore jokingly said he had no idea why Winehouse chose to include him in the lyrics, unless she wanted a word that rhymed with "door", or could not find one that rhymed with "
Connery". Following her death, the song re-entered the
UK Singles Chart at number 37. ==Track listings==