Vazquez started his acting career with filler parts in his mother's plays, which led to discovery by an agent who encouraged him to go to acting school. In the 1980s, he was lead guitarist for two
Billboard-charted rock bands. His musical skills led him to land the part of Flaco in the 1992 film
The Mambo Kings. He has also been in
Kill the Messenger (2014) starring
Jeremy Renner and directed by Michael Cuesta;
The Cobbler (2014) opposite
Adam Sandler,
Dustin Hoffman and
Steve Buscemi; and
Anesthesia (2015). In television, he has had many guest and recurring roles. In the TV sitcom
Seinfeld Vazquez played the role of Bob who stole the armoire from Kramer. In
Lifetime's series
The Lottery he starred as President Thomas Westwood and as The Reverend Emilio Sheehan in the NBC series
Midnight, Texas. He was a regular for both seasons of the
Starz drama
Magic City, where he portrayed Victor Lazaro, general manager of the Miramar Playa. Additionally, he has recurred in other television series, as Pedro in
FX's
Louie, as Christian in
CBS's
The Good Wife and as Det. Anthony Nikolich on the
HBO television series
Treme. In the streaming world, he has had recurring roles in several hit shows including
Netflix's
Russian Doll and
Apple TV+'s
Severance. Vazquez is a founding member of the LAByrinth Theater Company and served two terms as co-artistic director with
Stephen Adly Guirgis and
Mimi O'Donnell in
New York City. Vazquez starred on
Broadway in the Tony nominated
The Motherfucker with the Hat opposite
Chris Rock. For his portrayal of the eccentric Cousin Julio, he received nominations for a
Drama Desk Award, an
Outer Critics Circle Award and a
Tony Award for
Best Featured Actor in a Play. Additional theater credits include
The Last Days of Judas Iscariot (The Public Theater) opposite
Sam Rockwell, directed by
Philip Seymour Hoffman,
Terrence McNally's
Stendhal Syndrome,
Primary Stages with
Isabella Rossellini and Richard Thomas, and
The Floating Island Plays (Mark Taper Forum). ==Music career==