Calderon started her career at the Jacobi Medical Center. Her career has focused on elimination of
HIV/AIDS amongst at-risk populations and underserved communities. In the 2010s in
The Bronx, where Calderon spent part of her childhood, over 23,000 people were living with HIV/AIDS, and around one quarter were not aware they were carrying the virus. Calderon made
HIV testing part of routine medical care in
NYC Health + Hospitals. She developed Behavioral Intervention-Rapid HIV Testing Education & Follow-Up (BRIEF), which looked to improve awareness of HIV through rapid testing. During the
COVID-19 pandemic, Calderon was Chair of the Department of Emergency Medicine at the
Mount Sinai Beth Israel Hospital. Calderon's father died from the disease. This motivated her to ensure all hospitalized
COVID-19 patients would be able to hear the voice of people they knew. She investigated health disparities during COVID-19, and tried to persuade reluctant community members to get the vaccine. Calderon developed the first digital
HIV diagnostic and counseling program, which has been deployed in various clinical settings. ==Awards and honors ==