Zacharias Kopystensky was archimandrite of the Kyiv Pechersk Lavra in Ukraine. He is best known for his polemic work Palinodiia (1621/3), in which he defended Eastern Orthodoxy against the Ruthenian Uniate Church. He also translated the Horologion and the works of John Chrysostom. He succeeded Yelisey Pletenetsky as archimandrite in 1624.