Msutwana started her acting career whilst at university, having appeared on productions such as; King Lear, The Suit, Brink, Trojan Women. Her professional acting career began in 2007 where she portrayed a lead role on
SABC 1's drama series Society. She starred as Akua Yenana, a stockbroker then a lady of leisure until its departure in 2010. In 2009, she starred a main role as the bride, Ayanda, on the
White Wedding film alongside
Kenneth Nkosi, the groom, and
Rapulana Seiphemo, the best man. In 2013, she portrayed a main role on Mzansi Magic's
Zabalaza until its departure in 2015 which featured
Baby Cele. In 2016, on Mzansi Magic's drama series
Isikizi; she starred as Nomazwe, a mother who gives birth to a prince's son who is declared by the king's Sangoma (traditional healer) as a cursed newborn who'll grow to kill his father and marry his mother. She starred the role of princess Nomakhwezi on Igazi's Season 1, a
Shona and
Connie Ferguson production, alongside
Vatiswa Ndara,
Jet Novuka and the late
Nomhle Nkonyeni. She starred as the main role of
Vuyiswa Jola on
The Queen, alongside
Shona Ferguson and
Connie Ferguson from 2016-2022. She played the role of Zimkitha Mxenge in the show Gqeberha: The Empire for the entirety of the shows two season run. Her other television casts include Home Affairs, Mtunzini.com, Isidingo, Rhythm City and Soul City. and her other film casts include
The Algiers Murders and
A Small Town Called Descent. ==Selected filmography==