Pre-draft Jones received an invitation to the
Senior Bowl and had practiced well during the week leading up to the game. He led both teams and greatly improved his draft stock after making six receptions for 68 receiving yards and a touchdown for the North, who lost 16–15 to the South. He also attended the
NFL Combine and completed all the combine and positional drills. Jones also participated at East Carolina's
Pro Day, but opted to only run positional drills for team representatives and scouts. The majority of NFL draft experts and analysts projected Jones to be selected in the second round. He was ranked the fourth best wide receiver in the draft by
NFL media analyst
Mike Mayock, the fifth best wide receiver by
ESPN, and was ranked the sixth best wide receiver by
Sports Illustrated and NFLDraftScout.com.
Buffalo Bills 2017 The
Buffalo Bills selected Jones in the second round with the 37th overall pick in the
2017 NFL draft. On May 18, the Bills signed Jones to a four-year, $6.77 million contract with $3.84 million guaranteed and a signing bonus of $3.07 million. On September 10, 2017, Jones made his NFL debut. He had one reception for 21 yards in the 21–12 victory over the
New York Jets. On September 17, 2017, in Week 2, he barely missed on a potential game-winning pass from quarterback
Tyrod Taylor on fourth down late in the game of a 9–3 loss to the
Carolina Panthers. In Week 9, against the
New York Jets, he recorded six receptions for 53 yards and his first career receiving touchdown. In 15 games (10 starts) of his rookie year in 2017, Jones finished with 316 receiving yards and two touchdowns.
2018 Following his rookie season, Jones revealed he had played much of the year with a torn labrum in the shoulder, which required offseason surgery. Jones missed much of OTA's during the 2018 offseason due to another injury stemming from an offseason incident and started training camp on the non-football injury list. Jones recorded his first touchdown of the season against the
Houston Texans, a 16-yard pass from
Nathan Peterman (who entered the game after Allen was injured), that briefly gave the Bills the lead. Against the Jets in Week 10, Jones caught another touchdown to go with 93 receiving yards, a new career high. He recorded his first game with multiple receiving touchdowns two games later, catching two scores in a 21–17 loss to the
Miami Dolphins in Week 13. Jones finished the 2018 season as Buffalo's leading receiver. He caught 56 receptions for 652 yards and seven touchdowns.
Oakland / Las Vegas Raiders On October 7, 2019, Jones was traded to the
Oakland Raiders for a 2021 fifth-round pick. In the 2019 season, he appeared in 15 games and started nine. He finished with 27 receptions for 216 receiving yards. During the Raiders' first home game in
Allegiant Stadium upon
relocating to Las Vegas in 2020, Jones caught his first touchdown since 2018 in a 34–24 Raiders win over the
New Orleans Saints. Jones was fined by the NFL on October 5, 2020, for attending a maskless charity event hosted by teammate
Darren Waller during the
COVID-19 pandemic in violation of the NFL's
COVID-19 protocols for the 2020 season. Jones appeared in 16 games, of which he started two, in the 2020 season. He finished with 14 receptions for 154 receiving yards and one receiving touchdown. On March 19, 2021, Jones re-signed with the Raiders on a one-year contract. Against the
Baltimore Ravens in Week 1, Jones recorded a 31-yard touchdown to end the game as the Raiders won 33–27 in overtime. He played in all 17 games, of which he started nine. He finished with 47 receptions for 546 receiving yards and one receiving touchdown.
Jacksonville Jaguars in 2022. On March 16, 2022, Jones signed a three-year, $24 million contract with the
Jacksonville Jaguars. In Week 15 against the
Dallas Cowboys, Jones recorded 109 receiving yards and three touchdowns in the 40–34 victory. In the 2022 season, Jones appeared in 16 games and recorded 82 receptions for 823 receiving yards and five receiving touchdowns. In the
Wild Card Round against the Chargers, he had eight receptions for 74 receiving yards and one touchdown in the 31–30 victory. In the 2023 season, Jones appeared in nine games and started seven. He finished with 34 receptions for 321 yards and two touchdowns. On April 30, 2024, Jones was released by the Jaguars.
Arizona Cardinals On May 13, 2024, Jones signed a one-year contract with the
Arizona Cardinals. On August 23, Jones was suspended five games for violating NFL's personal conduct policy. He appeared in 11 games and had eight receptions for 84 yards. On March 11, 2025, Jones re-signed with the Cardinals on a one-year, $4.4 million contract. In eight appearances for the team, he recorded 12 receptions for 183 yards. On November 10, it was announced that Jones suffered a season-ending
torn Achilles in Week 10 against the
Seattle Seahawks. On November 12, he was placed on injured reserve. ==Career statistics==