This gene on the X chromosome is structurally similar to a related gene on the
Y chromosome (
ZFY). It encodes a member of the
krüppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic
transcriptional activation domain (AD), a
nuclear localization sequence (NLS) and a
DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse
embryonic and
adult hematopoietic stem cells showed that this gene was required as a
transcriptional regulator for
self-renewal of both stem cell types, but it was dispensable for growth and
differentiation of their progeny. Multiple
alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010] ==Clinical significance==