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Zimelidine

Zimelidine, formerly sold under the brand name Zelmid among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class, and the first SSRI antidepressant to be marketed. It is a pyridylallylamine, and is structurally different from other antidepressants.

Other uses
Zimelidine was reported by Montplaisir and Godbout to be very effective for cataplexy in 1986, back when this was usually controlled by tricyclic antidepressants, which often had anticholinergic effects. Zimelidine was able to improve cataplexy without causing daytime sleepiness. ==Side effects==
Side effects
Most often reported were: • Dry mouth, dryness of pharyngeal and nasal membranes • Increased sweating (hyperhidrosis) • VertigoNausea ==Mechanism of action==
Mechanism of action
The mode of action is a strong reuptake inhibition of serotonin from the synaptic cleft. Postsynaptic receptors are not acted upon. == Interactions ==
Interactions
MAO inhibitors – severe or life-threatening reactions possible == See also ==
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