Lopez was among the first employees to be hired at the
University of the Philippines Mindanao after its establishment in 1995, where she was information officer. She also worked at the Office of the Ombudsman in Mindanao (OMB-MIN) as graft investigator and prosecution officer up to 2007.
Davao City staff member (2007–2013; 2016–2022) In 2007, Lopez was hired as the
Davao City Council secretary under the vice mayorship of
Sara Duterte. Duterte also released various statements threatening to halt engagements between city hall and the city council based on the latter's actions, stating that the council "should learn to respect" her office as mayor, a position she held until Duterte's first mayoral term ended in 2013. Upon Duterte's election to a second term in 2016, Lopez was once again appointed city administrator, which she held until 2022. Soon after assuming office, Duterte decided to appoint four of her previous Davao City staff members, including Lopez, to her team at the
Office of the Vice President (OVP); Lopez's appointment as the OVP Chief of Staff was announced through Duterte's Facebook page on July 26, 2022. On November 3, 2024, Chua asked the
Department of Justice (DOJ) to issue an immigration lookout bulletin order (ILBO) against Lopez and six other OVP officials for continuously snubbing his committee's hearings regarding the OVP's alleged misuse of funds. However, by the evening of November 4, Lopez was able to leave the Philippines by boarding a plane at the
Ninoy Aquino International Airport (NAIA) headed to
Los Angeles,
California to visit her ailing aunt. On the following day, she along with six other OVP staff released a position paper that asks the committee to terminate its inquiry into their office's fund use, claiming that its hearings are "not in aid of legislation" and "violative of the rights of resource persons." In late November 2023, Lopez was briefly detained at the
Batasang Pambansa Complex after being cited in contempt by the
House Committee on Good Government and Public Accountability for sending a letter requesting the
Commission on Audit to not provide the committee with audit reports on the OVP's confidential expenses. During her detainment, Lopez initiated a midnight press conference through Zoom that featured Duterte's admission of communicating with a
contract killer to target president
Bongbong Marcos if Duterte is assassinated; Duterte had been preventing her transfer by House authorities to the
Correctional Institution for Women at the time. Immediately after the conference, Lopez was sent to the
Veterans Memorial Medical Center after suffering a panic attack, where she spent the remainder of her detainment. In December 2024, Lopez went on indefinite leave as OVP Chief of Staff, having previously expressed to Duterte during detainment her intention to resign. By February 3, 2025, Lopez was seen back at the OVP attending the office's flag-raising ceremony. ==Personal life==