The 1949 Campeonato Profesional was the second season of Colombia's top-flight football league. The tournament started on 25 April and ended on 4 December, with 14 teams competing against one another and playing each weekend. This tournament was famous for marking the beginning of El Dorado. Millonarios won their first title in this season, defeating Deportivo Cali in a tiebreaker final series which was played as both teams ended tied for first place with 44 points. Santa Fe, the defending champion, ended in third place with 39 points.