The first legs of the quarter-finals were played March 6–8, 2012, and the second legs were played March 13–15, 2012.
First leg: all times U.S. Eastern Standard Time (UTC−05:00); Second leg: all times U.S. Eastern Daylight Time (UTC−04:00) First leg ---- ---- ---- ;Notes • Note 1: Match was played at
Rogers Centre instead of
BMO Field, the home stadium of
Toronto FC, due to the unpredictability of March's weather conditions, and the stadium was not "winterized".
Second leg Monterrey won 7–2 on aggregate. ----
Santos Laguna won 7–3 on aggregate. ----
Toronto FC won 4–3 on aggregate. ----
UNAM won 9–2 on aggregate. ==Semi-finals==