Regular season Week 1: vs. Oakland Raiders The Colts began their
2013 season at home, for the first time since 2009, against the
Oakland Raiders. The Raiders, who received the opening kickoff, would turn the ball over on a Terrelle Pryor interception by Colts
cornerback Greg Toler. The interception would allow Andrew Luck and the Colts offense to drive down the field and score the first touchdown of the season on a pass from Luck to Reggie Wayne. Heading into the second quarter, the Colts defense would continue to prevent the Raiders from scoring, forcing Oakland to punt on second drive of the game. Luck would again lead the Colts down the field in an eight play, 69-yard drive that would result in a touchdown pass from Luck to
tight end Dwayne Allen, giving the Colts an early 14–0 lead. Pryor and the Raiders would respond for the first time on their next offensive drive, which ended in a touchdown run from Darren McFadden. Defensive stops by both the Colts and the Raiders would ensure no further scoring in the half and would allow Indianapolis to head into halftime with the 14–7 lead. Indianapolis was forced to punt on their first offensive possession of the second half, while the Raiders would drive down to the Colts 20-yard line and would score on a Sebastian Janikowski field goal, cutting the Colts lead to 14–10 lead. The Raiders would again begin to drive down the field and would score the go ahead touchdown early in the fourth quarter on a pass from Denarius Moore from Terrelle Pryor, giving the Raiders a 17–14 lead. Andrew Luck, on the next Colts offensive drive, would lead the team down the field, 71 yards in 11 plays, with Luck himself scoring the game-winning touchdown on a 19-yard run. Pryor and the Raiders would drive down to the Colts 24-yard line, though the drive would end with an interception by
Antoine Bethea, sealing the Colts victory. With the win, the Colts went to 1–0 on the season and extended their home winning streak to seven games. This was the last time the Colts would win a season opener until
2025.
Week 2: vs. Miami Dolphins The Colts faced the
Miami Dolphins in week two, a rematch of the 23–20 Colts victory during the
2012 season. This game also marked the second meeting between Andrew Luck of the Colts and Ryan Tannehill of the Dolphins, both sophomore quarterbacks. Indianapolis, who received the opening kickoff, were unable to score on their first drive, unlike the Dolphins who drove down 58 yards in six plays, while scoring on a Tannehill pass to wide receiver Mike Wallace, giving the Dolphins an early 7–0 lead. The Colts would respond with a long drive of their own, however they would be able to put it into the endzone, settling instead for an Adam Vinatieri field goal. The Dolphins would strike again, this time scoring in just two plays following a Tannehill 67-yard pass and a Lamar Miller touchdown run. The Colts, who entered the second quarter trailing 14–3, quickly scored their first touchdown on the day with an Andrew Luck pass to tight end Coby Fleener. After trading possessions, the Indianapolis offense would strike again, scoring their second touchdown of the quarter and taking the first lead of the day, though it would be taken away by a Caleb Sturgis field goal to end the half, with the teams going into halftime tied at 17. Indianapolis would drive down on their first possession of the second half, though a touchdown would be nullified by an illegal shift penalty and forcing the Colts to settle for a field goal. Midway through the third quarter, the Dolphins would score the go ahead touchdown on a Charles Clay run, putting them ahead 24–20. On their last offensive possession of the day, Luck and the Colts would drive down to the Miami 23-yard line, though the comeback would fall short following a sack of Luck on fourth down. With the loss, the Colts went to 1–1 on the season and lost their first home game since September 23, 2012.
Week 3: at San Francisco 49ers Week 4: at Jacksonville Jaguars Week 5: vs. Seattle Seahawks Week 6: at San Diego Chargers Week 7: vs. Denver Broncos Week 9: at Houston Texans The Colts fell behind 21–3 before rallying to defeat the Houston Texans on Sunday Night Football 27–24.
Week 10: vs. St. Louis Rams Week 11: at Tennessee Titans Week 12: at Arizona Cardinals Week 13: vs. Tennessee Titans Week 14: at Cincinnati Bengals With the loss, the Colts dropped to 8–5, however, they clinched the
AFC South division title after the Broncos defeated the Titans later in the evening.
Week 15: vs. Houston Texans With the win, the Colts improved to 9–5 and 12–0 at home against the Texans.
Week 16: at Kansas City Chiefs Week 17: vs. Jacksonville Jaguars With the win, the Colts were the only team during the 2013 season to sweep all of their division rivals. ==Standings==