November The season officially began on November 13 with a 78–65 victory over
Albany in the first game of the HoopHall Invitational at
Rupp Arena. The following night Kentucky defeated
NJIT 87–57 behind 26 points from Labissiere. Three nights later the team traveled to
Chicago for the
Champions Classic to play No. 5
Duke. The Cats defeated the Blue Devils 74–63 which was Kentucky's first victory over Duke since the
1998 NCAA tournament Kentucky returned home on November 20 to defeat
Wright State 78–63. Ulis led the team with 21 points and 5 assists. Kentucky entered its game against
Boston U. on November 24 ranked number one in the country for the first time this season. The Cats defeated the Terriers 82–62. The night after Thanksgiving, on November 27, Kentucky traveled to
Miami to play
South Florida in the Hoops Hall Invitational. Kentucky defeated the Bulls 84–63 despite losing Ulis in the first half to a hyper-extended elbow. On November 30 Kentucky returned home to defeat
Illinois State 75–63 behind 16 points from Murray.
December On December 3 Kentucky traveled to Los Angeles to play
UCLA for their first meeting ever in
Pauley Pavilion. UCLA defeated Kentucky 87–77 which was Kentucky's first regular season loss since March 8, 2014 at Florida. Kentucky returned home on December 9 to defeat
Eastern Kentucky 88–67 behind 22 points and 13 rebounds from Poythress. On December 12 Kentucky hosted
Arizona State and defeated the Sun Devils 72–58 behind 14 points and 7 rebounds from Lee. On December 19 Kentucky traveled to
Brooklyn to play in the annual
CBS Sports Classic against
Ohio State. Despite 33 points from Murray, the Buckeyes defeated UK 67–74. On December 26 Kentucky returned home to play in the annual
Battle for the Bluegrass against
Louisville. For the second consecutive year Ulis was named MVP of the game after a 21 points, 8 assist performance to lead Kentucky to a 75–73 victory. The win marked the seventh victory out of the last eight.
January Kentucky opened conference play against
Ole Miss on January 2 at Rupp Arena. Kentucky defeated the Rebels 83–61 behind 20 points and 10 assists from Ulis. On January 5 Kentucky traveled to
Baton Rouge to face
LSU. LSU defeated Kentucky 61–83 giving Kentucky its first SEC regular season loss since March 2014. Coming off the loss to LSU the team traveled to
Tuscaloosa to face off against
Alabama. Behind a career high from Poythress (25) Kentucky defeated the Tide 77–61. On January 12 Kentucky returned to Rupp Arena defeat
Mississippi State 80–74 behind 22 points from Murray. On January 16 Kentucky traveled to
Auburn to play
Auburn. Despite a 12-point second half lead, Kentucky lost to the Tigers for the first time in the last nineteen games 70–75. On January 21 Kentucky traveled to
Fayetteville to play
Arkansas. Behind a career-high 24 points from Ulis, Kentucky defeated Arkansas 80–66. The victory gave Calipari a victory in every SEC arena since becoming Kentucky's head coach in 2009–10. Two days later Kentucky returned to Rupp Arena to defeat
Vanderbilt 76–57 behind 21 points from Ulis. On January 28 Kentucky hosted
Missouri before their last non-conference game of the season. Kentucky defeated the Tigers 88–54 behind 20 points from Ulis and 18 points from Willis. For their last non-conference regular season game of the season Kentucky traveled to
Lawrence to face #4
Kansas in the
Big 12/SEC Challenge. The Wildcats came up short against the Jayhawks with an 84–90 overtime loss in one of the toughest venues in all of college basketball.
February On February 2 Kentucky traveled to
Knoxville to face
Tennessee. Despite having a 21-point lead in the first half, the Wildcats fell to the Volunteers 77–84. This was the largest lead that was lost in the John Calipari era at Kentucky. On February 6 Kentucky returned to Rupp Arena to host
Florida. The Wildcats defeated the Gators 80–61 behind a career-high from Murray (35). Murray's 35 points ties for the most by a freshman in Kentucky history. On February 6 Kentucky defeated
Georgia 82–48 behind 24 points from Murray. Kentucky held the Bulldogs without a made field goal for over 17 minutes. On February 13 Kentucky traveled to
Columbia to face
South Carolina. Despite Calipari being ejected with two technicals in the first minutes of the game, Kentucky dominated the Gamecocks 89–62. On February 18 Kentucky returned to Rupp Arena for a rematch with Tennessee. The Wildcats got revenge over the Volunteers with an 80–70 victory, their fourth in a row. On February 20 Kentucky traveled to
College Station to face
Texas A&M. The Wildcats fell to the Aggies in overtime 77–79 after a buzzer beating lay-up by A&M. On February 23 Kentucky returned to Rupp Arena for their second contest with Alabama. The Wildcats defeated the Crimson Tide 78–53 behind 23 points from Murray. On February 27 Kentucky traveled to
Nashville to face Vanderbilt in their second contest of the season. The Commodores defeated Kentucky 62–74 despite 33 points from Murray.
March On March 1 Kentucky traveled to
Gainesville for their second contest against Florida. In their last road game of the season Kentucky defeated the Gators 88–79 behind 20 points from Murray, his seventh straight game of 20 or more points. The game also saw the reemergence of Labissiere, who made the most of his first start since December 12 by chipping in 11 points and eight rebounds. On March 5 Kentucky hosted LSU for their second contest against the Tigers. In their last regular season game of the season Kentucky defeated the Bayou Bengals 94–77 to claim a share of their 47th SEC regular-season title. Willis returned for his first game since February 20 due to a sprained right ankle. Murray scored 22 points, Labissiere added 18 and Poythress scored 12 in his last game at Rupp Arena.
SEC Tournament Schedule {{CBB schedule end|poll=
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Eastern Time| region = E ==Honors==