Division One South comprised 20 clubs, 19 of which were in the division the previous season. •
FC Oswestry Town resigned before the start of this season, and subsequently folded. •
FC Isle of Man's application to join the
English football league system was successful, and the team was placed in this division. However, the club agreed to have its playing membership in the league suspended by mutual consent for the rest of this season because of
COVID-19 pandemic-related travel restrictions on the
Isle of Man.
Division One South table Prior to the first match(es) being played the
Pos column shows alphabetic sequence of teams rather than league position.
Division One South results Stadia and locations {{location map+ |North West England|float=left |width=400 == League Challenge Cup ==