The 2022–23 Iowa State Cyclones men's basketball team represented Iowa State University during the 2022–23 NCAA Division I men's basketball season. The Cyclones were coached by T. J. Otzelberger in his second season as head coach, and 10th season at Iowa State. They played their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference. They finished the season 19–14, 9–9 in Big 12 Play to have a two-way tie for 5th place. They defeated Baylor in the quarterfinals of the Big 12 Tournament before losing to Kansas in the semifinals. They received an at-large bid to the NCAA Tournament where they were eliminated in the first round by Pittsburgh.