The
2022–23 Premier League fixtures were released on 16 June 2022. The league season began with a home loss against
Brighton & Hove Albion on 7 August.
Pascal Groß scored twice in the first half for Brighton before they conceded an own goal by
Alexis Mac Allister in the second to give United their first ever home defeat to Brighton. Named in the starting line-up,
Lisandro Martínez and
Christian Eriksen made their debuts for United, as did
Tyrell Malacia, who came on as a substitute. United then suffered another defeat to
Brentford, the first time they had started a league campaign with consecutive losses since the
1992–93 season.
Josh Dasilva,
Mathias Jensen,
Ben Mee and
Bryan Mbeumo all scored without reply before the clock had reached 38 minutes. The rest of the game went goalless, but it meant United went bottom of the league table. This was United's seventh straight away defeat in the league, their worst streak since a run of 10 in the
1936–37 season, which ended in relegation from the First Division. That season, United lost both of their meetings with Brentford: 4–0 away on 10 October 1936 and 3–1 on 13 February 1937; those were United's most recent defeats to Brentford prior to this. Erik ten Hag became the first United manager since
John Chapman in 1921 to lose his opening two games in charge of the club. On 22 August, United achieved their first league victory of the season, a 2–1 home win against rivals Liverpool. Jadon Sancho scored 15 minutes into the first half and Marcus Rashford early in the second, before
Mohamed Salah scored a consolation goal that made him the fixture's outright top scorer with 10 goals. This was United's first league win against Liverpool since
March 2018. In the next match, United visited
Southampton on 27 August.
Bruno Fernandes scored the game's only goal with a volley as United won their first away match in the league and won back-to-back league matches for the first time since February 2022.
Casemiro made his United debut when he came on as a substitute in the 80th minute. On 1 September, United achieved a second away victory as they won 1–0 against
Leicester City. Sancho scored the only goal after 23 minutes as United won three league matches in a row for the first time since December 2021. On 4 September, United obtained their fourth consecutive league victory with a 3–1 home win against
rivals Arsenal.
Antony scored the opening goal 35 minutes into his United debut, before
Bukayo Saka equalised at the hour mark. Rashford then scored two goals in order to secure victory against Arsenal, who were on top of the league table, having started the season on a five-match winning streak. Following the
death of Queen Elizabeth II on 8 September, all league matches on the weekend of 10–12 September were postponed. United then announced that their home game against
rivals Leeds United, originally scheduled for 18 September, would also be postponed due to a police shortage ahead of the Queen's state funeral. United's break from league action was further extended by the September international window, which meant their first Premier League match in almost a month saw them face
Manchester City away in the
derby on 2 October.
Erling Haaland and
Phil Foden each scored twice for City in the first half to give the hosts a 4–0 lead at the break. Antony scored for United early in the second half, but Haaland and Foden both scored again to complete their hat-tricks before Anthony Martial came on to score two late goals for United. With a total of nine goals, it was the highest-scoring Manchester derby of all time. The next week, United travelled to play
Everton.
Alex Iwobi opened the scoring after just five minutes, but Everton led only briefly before Antony scored the equaliser, his third consecutive league game scoring. An injury to Martial saw him replaced by
Cristiano Ronaldo just before the half-hour mark, who only took 15 minutes to score the winning goal, assisted by Casemiro. It was Ronaldo's first open-play goal of the season and the 700th overall in his club career. On the next match United faced
Newcastle United in their first home league game in six weeks. Both teams had plenty of chances but ultimately had to settle for a goalless draw. Three days later, they hosted
Tottenham Hotspur. Fred scored his first goal of the season before Fernandes sealed the win. They visited
Chelsea three days later in the last game against a fellow top six side in 2022. Following a foul in the penalty area by Scott McTominay,
Jorginho slotted home the penalty three minutes from time, but Casemiro then headed home in the fourth minute of stoppage time – his first United goal – as United extended their unbeaten league record against the West London side to 10 matches, dating back to November 2017. United hosted
West Ham United on 30 October. Rashford scored his 100th club goal, which proved to be the sole goal of the game. The match was held
85 years to the start of United's run of including academy graduates in their matchday squads, which by this point already reached 4,163 consecutive matches. A week later United travelled to Aston Villa, in their manager
Unai Emery's first Premier League game since his days with Arsenal. A seventh-minute goal from Leon Bailey and a free kick from
Lucas Digne four minutes later gave Villa an early two-goal lead, before a shot from
Luke Shaw was deflected into his own net by
Jacob Ramsey. Four minutes into the second half, Ramsey redeemed himself and made it 3–1. This was United's first loss at
Villa Park in all competitions since
October 1999, and the first in the league since
August 1995. The following Sunday saw United travel to West London to face
Fulham for the last Premier League game prior to the World Cup. Eriksen opened the scoring with his first goal for the club with less than 15 minutes played, but as the game passed the hour mark, former United winger
Daniel James scored from close range to equalise.
Alejandro Garnacho, who was subbed on for Martial 11 minutes later, scored the winning goal in the final minute of added time. United's first action after the World Cup was a Boxing Day fixture against
Nottingham Forest. Following up a corner kick from Eriksen, Rashford scored the opening goal after just 18 minutes, four minutes before setting up for Martial. Fred scored the third goal three minutes from time following a pass from Casemiro to secure the three points. United's final game of the year saw them play
Wolverhampton Wanderers away. Rashford, who was benched for disciplinary reasons, scored the game's only goal to put United into the top four. United started the new year with a home game against
Bournemouth. Goals from Casemiro, Shaw and Rashford gave them a 3–0 win and strengthened the club's grip on the top four. Two weeks later, they welcomed Manchester City to Old Trafford for the second derby of the season.
Jack Grealish opened the scoring for City on the hour mark, before Fernandes scored an equaliser in the 78th minute; the goal was initially ruled out for an offside against Rashford, but a VAR review deemed Rashford not to have been interfering with play. Rashford then scored the winner four minutes later; it was his eighth goal in his last seven appearances. The win also extended United's winning run to nine in all competitions. Four days later, United travelled to Crystal Palace. Their nine-game winning run was brought to an end after Fernandes' first half goal was cancelled out by a second half stoppage time free-kick from
Michael Olise. This game saw
Wout Weghorst made his debut for the club. Four days later, United travelled to league leaders Arsenal. Rashford brought United forward before an equaliser by
Eddie Nketiah seven minutes later. Saka put Arsenal in front in the 53rd minute, but Lisandro Martínez scored his first United goal to equalise matters. Nketiah then scored the winner at the 90th minute, extended Arsenal's unbeaten league record this season to 13 matches and home record against United to five league matches; United's most recent league win at the
Emirates Stadium was on 2 December 2017. On 4 February, United faced Crystal Palace. A handball from
Will Hughes penalised Palace; Fernandes executed the penalty kick smoothly to open an early lead. Rashford then made it 2–0 after a pass from Shaw. After Casemiro received a red card after an altercation with Hughes,
Jeffrey Schlupp halved the deficit in the 76th minute.
Marcel Sabitzer came on to make his United debut in the closing minutes as they successfully defended the lead. Four days later Leeds came visiting right after the dismissal of their head coach
Jesse Marsch, with
Michael Skubala as his interim replacement. Within a minute,
Wilfried Gnonto scored for them. In the 48th minute,
Raphaël Varane scored an own goal from
Crysencio Summerville's cut-back to double Leeds' lead. Rashford pulled one back 14 minutes later, before Sancho equalised within eight minutes to earn United a point. United visited Leeds the following Sunday. Rashford broke the deadlock with a header at the 80th minute following a cross from Shaw, before Garnacho sealed the win with a strike assisted by Weghorst.
David de Gea made history as he became the first keeper to reach 400 Premier League appearances for Manchester United. In the next match, United faced Leicester at Old Trafford. Rashford scored in the 25th minute, breaking his best tally in a season, and doubled the lead in the 56th minute. Sancho then scored five minutes later to secure a 3–0 win. The scoreline meant that De Gea equalled
Peter Schmeichel's club record for most clean sheets. On 5 March, United visited
Anfield in search of a first win there since January 2016. Instead, braces from
Cody Gakpo,
Darwin Núñez and the fixture's top scorer, Mohamed Salah, as well as a closing goal from
Roberto Firmino gave Liverpool a 7–0 win, breaking the record set 128 years earlier for the biggest win in matches between the two teams. This was also United's
joint-biggest ever defeat and the heaviest since Wolverhampton Wanderers thrashed them by the same scoreline in
1931. The following Sunday, United faced Southampton at home. The match ended in a goalless draw after a second red card of the season for Casemiro for a challenge on
Theo Walcott, upgraded from a yellow card after an intervention from the
video assistant referee. After the international break, United travelled to Newcastle.
Joe Willock and
Callum Wilson scored for the home side without reply. Manchester United failed to win both league meetings against Newcastle for the first time since the
2015–16 season, and with just one point earned from a possible six, this league season was Manchester United's worst against Newcastle since they did the same in
2011–12. In the next match, United welcomed Brentford. A Rashford goal gave United their first league win since February and put them back in the top four. Three days later, they welcomed Everton at home. A goal each from Scott McTominay and Anthony Martial, both scoring in the league for the first time this season, secured the win. Eight days later, United visited Forest for their fourth and final meeting of the season. Antony scored after 32 minutes, before
Diogo Dalot scored his first Premier League goal after an assist by Antony. This became the third time that United won four matches against a single opponent in a season, after
Sheffield Wednesday in
1993–94 and Chelsea in
2010–11. United returned to Premier league action 11 days later at the
Tottenham Hotspur Stadium. The away side took an early lead through Jadon Sancho before Marcus Rashford scored a second just before half-time. In the second half,
Pedro Porro scored for Spurs and
Son Heung-min levelled the scores in the 79th minute to end United's five match winning streak against Tottenham Hotspur in the league. Three days later, United hosted Aston Villa, with Bruno Fernandes scoring the only goal of the game six minutes before half-time after a shot from Marcus Rashford was turned into his path by Villa goalkeeper
Emiliano Martínez. It marked the 100th career goal for Fernandes. United's next match was a rescheduled fixture against Brighton & Hove Albion on the 4th of May. The game was goalless heading into added time, before Brighton were awarded a penalty following a VAR review after Luke Shaw was judged to have handled the ball in the area while defending a corner. The spot kick was converted by Alexis Mac Allister, who had scored an own goal in the reverse fixture earlier in the season. United then travelled to London three days later to face West Ham United. David de Gea let a shot from
Said Benrahma slip through his hands in the 27th minute to gift the Hammers a win over United, the first time former manager
David Moyes has beaten them in the league. The following Saturday, United played Wolverhampton Wanderers at home. Anthony Martial scored a first half tap-in from a square pass by Antony, before Alejandro Garnacho marked his return from injury with a stoppage time goal to strengthen United's grip on 4th place in the league. A week later, United travelled to Bournemouth for their final away game of the season. Casemiro scored an acrobatic overhead kick for the only goal of the game and David de Gea's 17th clean sheet of the season confirmed him as the winner of the Premier League Golden Glove award for most clean sheets kept. Manchester United's penultimate league game was a 4–1 win over Chelsea. Goals from Casemiro and Martial gave United a two-goal lead at half-time, before a penalty from Fernandes and Rashford's 30th goal of the season doubled their lead, although
João Félix managed a late consolation strike for the Blues. The victory sealed a top-four finish for United and qualification for the
2023–24 UEFA Champions League group stage. The Red Devils ended their league season with a 2–1 victory at home to Fulham. The away side went ahead in the first half after a header from
Kenny Tete, but missed the chance to double their lead after De Gea saved a penalty from
Aleksandar Mitrović. United then fought back in the second half with Sancho and Fernandes getting on the scoresheet for a comeback win to ensure they would finish the season in third place.
Matches League table ==FA Cup==