Málaga After starting his youth career at
Maghreb de Fès and
Mohammed VI Football Academy, En-Nesyri joined
Málaga CF for a fee of €125,000 in 2015. Initially assigned to the
Juvenil squad, he made his senior debut for
the reserves on 16 April 2016, scoring the last goal in a 3–1
Tercera División away win against
Guadix CF. He netted back-to-back goals in the following three matches against
CD Huétor Tájar, River Melilla CF, and
FC Vilafranca, and went on to become an integral player for the reserve side which narrowly missed promotion to the
Segunda División B. On 8 July 2016, En-Nesyri was included in first team manager
Juande Ramos' pre-season squad, and scored a double in a 4–0
friendly win against
Algeciras CF eight days later. On 23 August 2016, after scoring six goals during the pre-season, Youssef En-Nesyri agreed to a contract extension until 2020. Three days later he made his professional – and
La Liga – debut, coming on as a late
substitute for
Keko in a 2–2 away draw against
RCD Espanyol. En-Nesyri scored his first professional goal on 21 September 2016, netting the winner in a 2–1 home victory against
SD Eibar, after coming on as a substitute for
Charles. He contributed with four goals in 25 league appearances during the
2017–18 campaign, as his side suffered relegation.
Leganés On 17 August 2018, following Málaga's relegation from La Liga, En-Nesyri signed a five-year contract with
CD Leganés in the main category. He scored his first goals in his ninth game, to earn a 2–2 home draw with nearby
Rayo Vallecano in the first leg of the last 32 of the Copa del Rey on 30 October, and on 23 November he netted his first league goal, the only one of a victory also at the
Estadio Municipal de Butarque against a
Deportivo Alavés team that was challenging for top spot. In late January to February 2019, En-Nesyri scored six goals in three games as Leganés avoided defeat: a brace in a 2–2 draw with Eibar, the late winner at Rayo and then all three goals against Real Betis; this last result made him the first
Pepinero to net a hat-trick in La Liga. Due to his performances, he was awarded the
Cinco Estrellas Player of the Month in January 2019 and February 2019.
Sevilla On 16 January 2020,
Sevilla signed Youssef En-Nesyri from Leganés for a reported €20 million, on a contract lasting to June 2025; the Andalusians had recently sold their strikers
Mu'nas Dabbur and
Javier Hernández. He debuted two days later in a 2–1 loss at
Real Madrid, as a 65th-minute substitute for
Munir El Haddadi, and on his first start on 9 February he opened the scoring on a trip to
Celta Vigo with the same result. En-Nesyri made his debut in European competitions on 20 February 2020, in the
UEFA Europa League last 32 first leg away to
CFR Cluj in Romania. He scored the late equaliser in a 1–1 draw, that put his team through on the
away goals rule. On 6 August 2020, he scored a goal in a 2–0 win over
Roma in the round of 16. Sevilla went on to win the
2020 UEFA Europa League. On 4 November 2020, En-Nesyri scored a brace in a 3–2 win over
Krasnodar in the
UEFA Champions League group stage, his first goals in the competition. On 8 December, he scored another brace in a 3–1 away win over
Rennes. In January 2021, En-Nesyri scored hat-tricks in home wins over
Real Sociedad (3–2) and
Cádiz (3–0). On 9 March 2021, he scored a brace in a 2–2 away draw against
Borussia Dortmund in the second leg of the Champions League round of 16; however, Sevilla were eliminated as they lost 4–5 on aggregate. On 14 March, he scored the winning goal in a 1–0 win over
Real Betis in the
Seville derby. On 4 April 2021, En-Nesyri marked his hundredth match played for the team against
Barcelona. On 22 April 2021, he scored the only goal in a 1–0 victory against
Levante, thus becoming the highest goal scoring Moroccan in a single La Liga season with 17 goals, surpassing
Youssef El-Arabi's 16 goal mark, he ended the season with 18 La Liga goals. In the
2022–23 UEFA Europa League, En-Nesyri scored a brace in a 3–0 victory against
Manchester United in the
quarter-finals. Three days later, he scored the winning goal in a 2–1 victory against
Valencia. On 11 May 2023, En-Nesyri scored Sevilla's first leg goal in a 1–1 draw away at the
Juventus Stadium against
Juventus in the Europa League semi-finals. In the
2023 UEFA Super Cup, he scored a goal in a 1–1 tie, before losing on penalties to
Manchester City. On 4 October 2023, En-Nesyri scored a goal in a 2–2 draw against
PSV in the
2023–24 UEFA Champions League, thus making him the best Moroccan scorer in the history of the
UEFA Champions League with 9 goals, surpassing
Marouane Chamakh, who scored 8 goals. On 1 November 2023, En-Nesyri was nominated for the 2023
African Footballer of the Year by
CAF. On 5 February 2024, he scored a brace in a 2–1 victory against
Rayo Vallecano, making him the highest-scoring Moroccan player in La Liga's history, he surpassed the previous record of 58 goals held by the late Atlético de Madrid and Morocco striker
Larbi Benbarek.
Fenerbahçe On 24 July 2024, En-Nesyri joined
Fenerbahçe on a five-year contract for €19.5 million, making him the most expensive player in the club's history and broke the transfer record in
Süper Lig. On 6 August 2024, En-Nesyri made his debut for the club in a
Champions League third qualifying round match against
Lille. On 17 August 2024, he made his first
Süper Lig appearance and scored his first goal, a header, in an away match against
Göztepe. On 24 October 2024, he scored his first continental goal against
Manchester United in a 1–1 tie
UEFA Europa League league phase match. On 9 January 2025, he made his
Turkish Cup debut in
group stage a 3–0 win over
Kasımpaşa, he also scored a goal in the match.
Al-Ittihad On 3 February 2026, En-Nesyri joined
Saudi Pro League club
Al-Ittihad. ==International career==