3-Hydroxypropionic acid

3-Hydroxypropionic acid can be obtained by base-induced hydration of acrylic acid followed by reacidification. Another synthesis involves cyanation of ethylene chlorohydrin followed by hydrolysis of the resulting nitrile. Hydrolysis of propiolactone is yet another route. Propiolactone, the dehydrated derivative of 3-hydroxypropionic acid, is produced by reaction of ketene and formaldehyde. It can also be produced from glucose via pyruvate and malonyl coenzyme A. ==Potential applications==

3-Hydroxypropionic acid is of interest as a bio-derived precursor to acrylic acid. The method combines the high-molecular weight and control aspects of ring-opening polymerization with the commercial availability of the beta hydroxy acid, 3-hydroxypropionic acid which is abbreviated as 3-HP. Since 3-HPA can be derived from biological sources, the resulting material, poly(3-hydroxypropionic acid) or P(3-HPA), is biorenewable. ==Genetically encoded 3-hydroxypropionic acid inducible system==

3-Hydroxypropionic acid can be produced by engineered microbes. A genetically encoded 3-hydroxypropionic acid inducible system has been characterized in bacteria demonstrating that such system in combination with fluorescent reporter protein can be utilized as a biosensor to measure intracellular and extracellular 3-HP concentrations by fluorescence output. ==See also==