Market4-Benzylpiperidine
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4-Benzylpiperidine

4-Benzylpiperidine is a drug and research chemical used in scientific studies. It has been encountered as a designer drug.

Pharmacology
4-Benzylpiperidine acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an EC50 of 109nM (DA), 41.4nM (NE), and 5,246nM (5-HT). It also functions as a weak monoamine oxidase inhibitor (MAOI) ( = 130μM for and 750μM for ). The drug has a fast onset of action and a short duration. ==Synthesis==
Synthesis
4-Cyanopyridine can be reacted with toluene to give 4-benzylpyridine. Catalytic hydrogenation of the pyridine ring then completes the synthesis. ==Applications==
Applications
RMI-10608 is a derivative of 4-benzylpiperidine and analog of haloperidol that was discovered to have potential use in treating psychosis and preventing brain damage by virtue of its NMDA antagonist pharmacology. == See also ==
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