Pre-draft Rouse entered the
2007 NFL draft as one of the top prospects at safety with his unusual combination of size, strength and speed. At 6'4, 223 pounds, he ran 4.59
40-yard dash at the NFL Combine. On June 8, he signed a four-year, $2.3 million contract with the Packers. After an injury to starting safety
Nick Collins, Rouse made his first NFL start on November 11, during a 34–0 victory over the
Minnesota Vikings. On November 18, Rouse recorded his first interception, when he picked off a
Vinny Testaverde pass on
Carolina Panthers' opening possession in a 31–17 victory over the Panthers. The following week, in a 37–26 win over the
Detroit Lions, Rouse recorded his second career interception in just his second career start. He was nominated for the week 12
Diet Pepsi Rookie of the Week award for his performance against the
Detroit Lions where he made a key game-changing interception against fellow rookie
Calvin Johnson. He finished his rookie campaign with 25 total tackles (22 solo tackles, two assists), four pass deflections and two interceptions while playing in 11 total games, starting in three of them. Rouse helped Green Bay win the 2007 NFC North division championship. The Packers finished the season losing to the New York Giants 23–20 in the NFC championship game, missing out on going to
Super Bowl XLII. Rouse entered the 2008 season as the backup strong safety behind starter
Atari Bigby but an injury to Bigby during the Week 2 matchup at
Detroit promoted Rouse to starting strong safety for the Packers' third game of the season against the
Dallas Cowboys and the fourth against the
Tampa Bay Buccaneers. After sustaining a knee injury in the 4th quarter against Tampa Bay, Rouse was inactive for the Packers' next contest against the
Atlanta Falcons. With Bigby also still out with an injury, Rouse was reinserted into the starting line up for the next two games against the
Seattle Seahawks and the
Indianapolis Colts. Against the Colts, Rouse had seven tackles, two pass defenses, and an interception which he returned 99 yards for a touchdown, tying the longest interception return in Packers history. He was named NFL Defensive player of the week for that performance. After
Atari Bigby returned from injury, Rouse returned to his backup role for the next couple of games until he was injured after his interception in the
Monday Night Football game at
New Orleans. Rouse was inactive for the next contest vs
Carolina. Rouse again entered the season as a backup but started in Week 2 against the
Cincinnati Bengals in place of the injured Atari Bigby. He recorded 9 tackles, 2 assisted, in the game. Rouse was cut by the Packers the following Wednesday, on September 23, 2009, and replaced by
Matt Giordano.
Later career Rouse was claimed off waivers by the
New York Giants on September 24, 2009, after
Kenny Phillips was placed on
injured reserve. He was released on March 6, 2010. Rouse signed with the
Arizona Cardinals on August 3, 2010. He was waived on August 18. After being released by the Cardinals, Rouse signed with the
Omaha Nighthawks of the United Football League (UFL) for the 2010 season. Rouse continued with the UFL for the 2011 season, joining the
Virginia Destroyers for the 2011 season. A highlight of Rouse's time with the Destroyers was the
2011 UFL championship game, in which Rouse recorded three interceptions en route to a 17–3 win; Rouse was designated the game MVP. ==Political career==