Ismaily Hegazi's professional playing career began on 24 November 2009, when he made his debut with Egyptian Premier League club
Ismaily playing as a
full back.
Fiorentina On 22 December 2011, the Egyptian club announced having made a deal with Italian side
Fiorentina in exchange for €1.5 million. The Egyptian company received a 15% sell on fee. Hegazi was given the number 3 shirt at Fiorentina. He made his unofficial debut for the club playing 30 minutes in a friendly against
Viareggio. On 18 November 2012, he played 15 minutes in his official debut against
Atalanta and scored his first goal for La Viola later that month in the second half of a
Coppa Italia match against
Juve Stabia on 28 November. On 12 December, Fiorentina announced that Hegazi had completed surgery after sustaining a severe leg injury in training. The club also announced that he had undergone reconstructive surgery on his anterior cruciate ligament. The expected recovery period before the player could return to sports activity was 5–6 months. In September 2013, he suffered another blow as he injured the same ligament again in training and took him out for six months making him miss most of the season. On 8 December 2014, Fiorentina announced that the player would be released in January 2015, along with
Octávio,
Mounir El Hamdaoui,
Oleksandr Iakovenko and
Joshua Brillante.
Perugia loan On 2 February 2015, Hegazi joined
Serie B side
Perugia on loan for the rest of
2014–15 Serie B. He made his debut for the club in a 3–1 loss to
Vicenza, playing the whole 90 minutes. It was his first complete match in Italy.
Al Ahly SC On 1 September 2015, Hegazi joined
Egyptian Premier League side
Al Ahly of Cairo on a five-year contract.
West Bromwich Albion in 2017 On 17 July 2017, Hegazi joined
Premier League side
West Bromwich Albion on loan from
Al Ahly until the end of the
2017–18 season, with Albion holding an option to trigger a permanent transfer. Hegazi made his Premier League debut for West Brom on 12 August, scoring a headed goal in a 1–0 win against
AFC Bournemouth and winning the man of the match award. In the following match he received the award for the second time in a row, as West Brom defeated hosts
Burnley and made their best start to a top flight campaign since the
1978–79 season. On 18 December 2017, West Brom exercised the option to sign Hegazi permanently, however he could not help save the club from relegation, ending their eight-year stay in the Premier League. Hegazi made 38 league appearances in the 2018/19 season and scored his only goal in a 2–1 win away at
Swansea. West Brom went on to lose to local rivals
Aston Villa in the Championship play-off semi final. In July 2019, after undergoing ankle surgery, it was announced that he would miss the first few weeks of the
2019–20 season.
Al-Ittihad (loan) On 26 October 2020, Hegazi joined
Saudi Pro League club
Al-Ittihad on loan from West Bromwich Albion until the end of the
2020–21 season.
Al-Ittihad After the
2020–21 season, Hegazi joined Al-Ittihad permanently. In the
2022–23 season, Hegazi won Al-Ittihad's first ever
Saudi Super Cup. He also helped the club win their ninth
league title, refusing to leave the pitch after an injury during the title-winning game of the season.
Neom On 21 July 2024, Hegazi joined
Saudi First Division League club
Neom on a two-year deal. ==International career==