Upon graduation, Sheikha al-Mayassa established the NGO
Reach Out To Asia. This organization is a philanthropic effort inspired by the desire to help the victims of recent natural disasters in Asia by providing quality education; it also celebrated the occasion of the 2006 Asian Games in Doha. Sheikha al-Mayassa is the chairperson of
Qatar Museums is responsible for cultivating significant cultural events in the region. Sheikha al-Mayassa is chairperson of the
Doha Film Institute (DFI), which she founded in 2010. The institute partnered with the
Tribeca Film Festival to produce several annual iterations of the
Doha Tribeca Film Festival. In February 2013, they announced a $100 million feature film fund with
Participant Media, a production company founded by
billionaire Jeffrey Skoll, who was the first employee and first president of internet auction firm
eBay. Fashion Trust Arabia (FTA) launched in September 2018 under the patronage of Sheikha Moza bint Nasser as honorary chair and co-chaired by Sheikha al-Mayassa and
Tania Fares (Founder of Fashion Trust). FTA is the only initiative of its kind operating in the Arab world, dedicated to finding and nurturing talented designers. She is a member of the board of trustees at
Qatar Foundation. In 2018, she was named to a three-year term on the
Rhode Island School of Design board of trustees. In 2021, she became vice chairman of the Education Above All Foundation and an independent director of
Soho House. She is a member of the Leadership Council of
The Democracy & Culture Foundation. In April 2023, Sheikha al-Mayassa was a speaker at the "Art for Tomorrow" conference in
Italy, organized by the Democracy & Culture Foundation in collaboration with The New York Times. In December 2023, she launched her podcast, "The Power of Culture", which focuses on the cultural scene in Qatar. She is a member of the environmental council of the
Museum of Contemporary Art, Los Angeles and of the collections council at The
Guggenheim Museum. ==Art collecting==