Early career Transitioning from
kickboxing, Pereira made his professional
mixed martial arts debut in 2015 at
Jungle Fight 82 against Quemuel Ottoni, losing the fight via submission. He continued at Jungle Fight subsequently racking up two straight victories against Marcelo Cruz and Marcus Vinicius Silveira, with a KO and TKO respectively. Pereira announced he had signed a contract to face Diego Henrique da Silva in the Brazilian edition of
Dana White's Contender Series on August 10, 2018. However, the bout never materialized as
Glory did not permit Pereira to compete. On 22 October 2020, news surfaced that Pereira had signed a contract with
Legacy Fighting Alliance and he then made his promotional debut against Thomas Powell on 20 November 2020. He won the fight via knockout in round one.
Ultimate Fighting Championship On 3 September 2021, Pereira signed with the
UFC. He made his promotional debut against
Andreas Michailidis on 6 November 2021, at
UFC 268. He won the fight via technical knock out in round two. This win earned him a
Performance of the Night award. Pereira faced
Bruno Silva on 12 March 2022, at
UFC Fight Night 203. Pereira outstruck Silva for all three rounds and won the fight via unanimous decision. Pereira was scheduled to face
Sean Strickland on 30 July 2022, at
UFC 277. However, the promotion decided to move the pairing to
UFC 276 on 2 July 2022. Pereira won the fight after knocking Strickland out in the first round. This win earned him a
Performance of the Night award, and
Crypto.com Fan Bonus of the Night third place award which paid in bitcoin of US$10,000.
UFC Middleweight Championship Pereira faced
Israel Adesanya for the
UFC Middleweight Championship on 12 November 2022, at
UFC 281. He won the bout via technical knockout in the fifth round. This win earned him the
Performance of the Night award. A rematch between Pereira and Adesanya for the
UFC Middleweight Championship took place on 8 April 2023, at
UFC 287. He lost the bout via knockout in the final minute of round two.
Move to Light Heavyweight Pereira was often noted for his large frame for his weight class and ability to comfortably
cut large amounts of weight. According to Pereira, he would weigh about 215 pounds on fight night when fighting as a middleweight (after dehydrating to the 185-pound limit at the weigh-in), and still 225 to 235 pounds as a light heavyweight. For comparison, his longtime rival Israel Adesanya typically weighed 196 pounds on fight night. On 13 April 2023, Pereira announced via Twitter that he was moving up to the
Light Heavyweight division. Pereira faced former
UFC Light Heavyweight champion
Jan Błachowicz on 29 July 2023 at
UFC 291. He won the back-and-forth fight via split decision. 22 out of 26 media outlets scored the bout for Pereira.
UFC Light Heavyweight Championship Pereira faced former
UFC Light Heavyweight champion
Jiří Procházka for the vacant
UFC Light Heavyweight Championship belt on 11 November 2023, at
UFC 295. He won the bout via TKO stoppage in the second round to win the title. This fight earned him the
Performance of the Night award. This victory made Pereira the 9th fighter in UFC history to become
champion in two different weight divisions. Pereira made his first title defence against former
UFC Light Heavyweight champion
Jamahal Hill, on 13 April 2024, at
UFC 300. He won the fight by knockout in the first round after a left hook. On two weeks notice, replacing the main event bout between
Michael Chandler and
Conor McGregor, who was injured, Pereira faced
Jiří Procházka in a rematch on 29 June 2024, at
UFC 303. After knocking Prochazka down in the last second of the first round with a left hook, he was able to win the bout with a head kick knockdown followed by punches early in the second round. This fight earned him another $50,000
Performance of the Night award. On an interview, Pereira's coach later revealed that Pereira received a $303,000 bonus for his performance at
UFC 303. Pereira made his third title defense against
Khalil Rountree Jr. on 5 October 2024 at
UFC 307. He won the fight by technical knockout in the fourth round. This fight earned him his first
Fight of the Night award. Pereira set the record for the shortest time for three title defenses in the UFC at 175 days, beating the previous record of 189 days by
Ronda Rousey, and became the seventh UFC fighter to record three title defenses in a calendar year. Pereira faced former title challenger
Magomed Ankalaev on 8 March 2025 at
UFC 313. He lost the title by unanimous decision. 11 out of 21 media outlets scored the bout for Ankalaev. Pereira competed for the championship against
Magomed Ankalaev in a rematch on 4 October 2025 at
UFC 320. He reclaimed the championship by technical knockout via punches and elbows in the first round. This fight earned him another
Performance of the Night award. Following the fight, Pereira expressed his desire to fight former
UFC Heavyweight Champion Jon Jones at the
UFC Freedom 250 event, a match-up supported by Jones. It was announced on 27 February 2026, that
Jiří Procházka and
Carlos Ulberg would be headlining
UFC 327 for the vacant
UFC Light Heavyweight Championship resulting in Pereira officially vacating the title.
UFC Heavyweight Championship Pereira is scheduled to attempt to be the first UFC fighter to win titles in three divisions by competing for the interim heavyweight championship against former interim champion
Ciryl Gane on 14 June 2026 at
UFC Freedom 250. On 11 April 2026, it was announced that Pereira will be a recipient of the 2026 UFC
Forrest Griffin Community Award for his institute "Instituto Poatan" which supports underserved youth in São Paulo, Brazil. ==Fighting style==