The event was held during the UFC's 10th annual International Fight Week. The 2022
UFC Hall of Fame induction ceremony also took place during the week. A
UFC Middleweight Championship bout between current champion
Israel Adesanya and
Jared Cannonier headlined the event. A
UFC Featherweight Championship trilogy bout between current champion
Alexander Volkanovski and former champion
Max Holloway took place at this event. The pairing first met at
UFC 245, where Volkanovski defeated Holloway via unanimous decision to capture the title. Their second meeting took place at
UFC 251, with Volkanovski successfully defending the title via split decision. They were originally expected to meet for the third time at
UFC 272, but Holloway withdrew due to an aggravated previous injury. A women's flyweight bout between former
Strikeforce and
UFC Women's Bantamweight Champion Miesha Tate and former
Invicta FC Bantamweight Champion (also former
UFC Women's Flyweight Championship challenger)
Lauren Murphy was expected to take place at
UFC on ESPN 36. However, the bout was moved to this event for unknown reasons. In turn, a week before the event, Murphy pulled out after she
tested positive for COVID-19. The bout was then rescheduled to
UFC on ABC: Ortega vs. Rodríguez. A middleweight bout between
Uriah Hall and
André Muniz took place at the event. The pairing was originally scheduled to meet as
UFC on ESPN: Luque vs. Muhammad 2 but Hall withdrew for unknown reasons. A women's flyweight bout between former
UFC Women's Flyweight Championship challenger
Jessica Eye and
Casey O'Neill was expected to take place at the event. However, O'Neill withdrew in late April due to a torn ACL and was replaced by
Maycee Barber.
Sean Strickland was expected to face former
Glory Middleweight and
Light Heavyweight Champion Alex Pereira in a middleweight bout at
UFC 277. However, the promotion decided to move the pairing to this event. A lightweight bout between
Bobby Green and
Jim Miller was previously booked twice, but was canceled on both occasions: first at
UFC 172 in April 2014, when Green pulled out due to an elbow injury. Green also pulled out of the second booking at
UFC 258 in February 2021, when he collapsed after the weigh-ins and was deemed unfit to compete. They were then expected to meet at this event. In turn, Green withdrew again for unknown reasons and was replaced by former
UFC Lightweight Championship challenger
Donald Cerrone in a welterweight bout. Miller and Cerrone previously met 8 years prior at
UFC Fight Night: Cowboy vs. Miller which Cerrone won by second-round knockout. ==Results==