At Moscow State University he studied philosophy, graduating in 1951. He moved to
Stalingrad where he taught high-school history before returning to Moscow to join the Institute of Oriental Studies as "a specialist in Tamil languages and
Hindu studies." He compiled the first Russian–Tamil dictionary in 1960. In 1963, influenced by
Juri Lotman who was working in
Tartu University, he was involved with Lotman,
Vyacheslav Ivanov,
Vladimir Toporov and others, in the establishment of
Tartu-Moscow Semiotic School. The School developed the theoretical foundations and nomenclature for a new approach in
semiotics for the study of society, consciousness and culture. In 1964, Piatigorsky's friend, poet
Joseph Brodsky, was handed down a five-year sentence of internal exile. The following year, in support of the writers
Yuli Daniel and
Andrey Sinyavsky, Piatigorsky with other Russian intellectuals: His investigations and theoretical observations of the role played by thinking and philosophy in ancient
South Asian culture and society were viewed with suspicion by some as a subtly indirect way of attacking the Soviet system. Knowing themselves to be likely targets of KGB surveillance, he and his fellow Indologists would gather in a room of the
Moscow Institute of Oriental Studies where they would enter into "fiery debates... in Sanskrit." The School remains virtually unknown in the West because its members were forced to operate behind the "Iron Curtain" in a context of severely reduced operational visibility and Soviet-style repression. One of his friends was also an indologist and culture theoretician David Zilberman, who in 1968–1972 was a postgraduate student working under prof. Yuri Levada. Together they used to discuss problems of consciousness development. After they both migrated they kept friendship and continued research co-operation till Zilberman's death in July 1977. Piatigorsky's book"
Myshlenie i nablyudenie" (Thinking and Observation), published in Riga in 2002, was dedicated to David Zilberman and included an explicit confession of Zilberman's influence on the author's thought. In 1972, Piatigorsky's Buddhist teacher
Dandaron was arrested by Soviet authorities. A number of Dandaron's students were imprisoned. Dandaron was sent to a Soviet labor camp where he perished in 1974. During the same period, Mamardashvili and Piatigorsky co-authored: "Symbol and Consciousness: Metaphysical Discussion of Consciousness, Symbolism and Language" Jerusalem (1982), in Russian. This abstract and complex text, combining Western and Eastern terms, is considered by some to be the most significant philosophical work written in the Russian language. ==Leaving Soviet Union and career at SOAS, University of London==