2013–2018: Maiden Challenger title, top 150 Popyrin entered his first
ITF Futures professional tournament in October 2013 at 14 years of age where he lost a first round qualifying match to Slovakian Martin Beran in
Madrid. He secured his first professional qualifying win a year later in another Spanish ITF Futures tournament but failed to qualify for the main draw when he lost in the second round qualifying match. At the beginning of 2016, at the age of 16, Popyrin contested his first
ATP Challenger Tour tournament after receiving a wildcard from
Tennis Australia to compete in the
2016 Canberra Challenger. He was defeated in the first round by future top 10 player
Diego Schwartzman. In July 2016, he secured his first professional main draw win in an Italian ITF Futures tournament by defeating local talent Tommaso Roggero in straight sets before retiring hurt in the second round. Popyrin continued to play ITF Futures tournaments for the remainder of 2016 and ended the year with a world ranking of No. 1155. He won his first professional ITF title in July 2017 at the Poland F4 in
Mragowo, Poland. This victory broke Popyrin into the top 1000 for the first time. He played several more ITF and Challenger tournaments for the remainder of 2017 and ended the year with a ranking of 622. Popyrin started the 2018 season ranked No. 622, achieving a career-high ranking 25 times over the course of the season peaking at No.147 in November. In January 2018, he qualified for an
ATP World Tour tournament for the first time at the
Sydney International beating
Nicolas Mahut and
Federico Delbonis. He lost in round one to
John Millman. Later in January, Popyrin made his Grand Slam debut at the
2018 Australian Open after being awarded a wildcard. He lost in round 1 to
Tim Smyczek. Popyrin spent the next six months in Europe playing in challenger tournaments, increasing his ranking. In August 2018, Popyrin qualified for and won his first
Challenger title at the
Jinan International in China beating
James Ward in the final, becoming the third youngest teenager in 2018 to win a professional Challenger title. Popyrin continued to perform well and broke into the world's top 200 in late August. In October, Popyrin qualified for his second ATP World Tour main draw at the
Stockholm Open, where he again lost to John Millman in round one. The following week, Popyrin again qualified for a main draw, this time at
Swiss Indoors beating
Benoit Paire and
Mackenzie McDonald. He defeated compatriot
Matthew Ebden for his first
ATP World Tour win. Popyrin ended 2018 with a singles rank of No. 147.
2019–2020: First major win, top 100 debut Popyrin commenced 2019 with wildcards into the
Brisbane International and
Sydney International, losing in the first round in both. He also received a wildcard in the
Australian Open, and achieved his first Grand Slam win by defeating
Mischa Zverev in straight sets. Popyrin followed this up by beating
Dominic Thiem and lost in the third round to
Lucas Pouille in closely contested five sets. During the first half of 2019 Popyrin qualified for the main draws of the ATP 250 tournaments in New York and Estoril, ATP 500 in Acapulco and Masters 1000 in Indian Wells and Monte Carlo. Following his success on the ATP tour, Popyrin was awarded a main draw wildcard into
French Open. In the first round Popyrin defeated France's
Ugo Humbert in four sets winning his first Roland Garros men's main draw match. He lost to
Laslo Djere in the second round. He broke into ATP top 100 for the first time at World No. 99 on 24 June 2019. In July 2019 Popyrin qualified for the main draw of the
2019 Wimbledon Championships Popyrin lost to
Daniil Medvedev in the second round. In the same month, Popyrin received his first direct acceptance into ATP 250 tournament in
Atlanta, where he lost in the quarterfinals. 2019 was a breakout year for Popyrin. He played at least second round in all four Grand Slams – 3rd round of Australia Open, 2nd Round of Roland Garros, 2nd Round of Wimbledon and 3rd Round in US Open losing in four closely contested sets to
Matteo Berrettini. In 2019 Popyrin qualified for 10 Professional tournaments tying the record set by Mischa Zverev in 2016. The Australian ended 2019 with an ATP singles rank of world No. 97.
2021: First ATP title Popyrin received a third wildcard into the main draw of the
2021 Australian Open similar to every year since 2018, with the exception of the
2020 Australian Open where he entered the main draw as direct entry. In the first round he defeated 13 seed
David Goffin after saving four match points in 3 hours 43 minutes. He then lost in the second round to
Lloyd Harris. In February, Popyrin entered the
Singapore Open and defeated
Marin Čilić in the semi-final and
Alexander Bublik in the final to win his first ATP title and achieved a career high singles ranking of 82. At the
2021 French Open, Popyrin lost to
Rafael Nadal in the first round. At the
US Open, Popyrin matched his career-best result, progressing through to the third round, which included a win over
Grigor Dimitrov, Popyrin's fourth career top-20 win and third achieved in 2021. Popyrin ended 2021 with an ATP singles ranking of world No. 61.
2022: Second Challenger title, out of top 100 Popyrin started his 2022 season at the
Melbourne Summer Set 1. He lost in the second round to
Tallon Griekspoor. In
Sydney, he was defeated in the first round by
Pedro Martínez. At the
Australian Open, he lost in the first round to
Arthur Rinderknech in five sets. After the Australian Open, Popyrin competed at the
Open Sud de France. He lost in the first round to fifth seed
Filip Krajinović. In
Rotterdam, he lost in the first round to
Karen Khachanov. Seeded seventh at the
Open 13 Provence, he was defeated in the first round by qualifier
Roman Safiullin. At the
Dubai Championships, he fell in the final round of qualifying to
Jiří Veselý. However, due to
Félix Auger-Aliassime withdrawing from the tournament due to a back injury, Popyrin entered the main draw as a lucky loser. He beat world No. 19,
Nikoloz Basilashvili, in the first round. He lost in the second round to qualifier
Ričardas Berankis. In March, he played at the
BNP Paribas Open. He was defeated in the first round by qualifier
Tomáš Macháč. At the
Arizona Classic, he lost in the first round to second seed
Lorenzo Musetti. In
Miami, he was defeated in the second round by 21st seed and world No. 23,
Marin Čilić. Popyrin started his clay-court season at the
Barcelona Open. He fell in the first round of qualifying to
Andrea Pellegrino. At the
Estoril Open, he lost in the first round of qualifying to
Pierre-Hugues Herbert. Making it through qualifying at the
Open du Pays d'Aix, he was defeated in the first round by fifth seed
Pablo Cuevas. Popyrin won his second ATP Challenger Tour title at the
BNP Paribas Primrose Bordeaux with a win over sixth seed
Quentin Halys in the final.
2023: Cincinnati quarterfinals, top 10 win Popyrin started his season at the
Adelaide International 1. After making it past qualifying, he upset second seed and world No. 6
Félix Auger-Aliassime, in the first round in straight sets. He went on to reach the quarterfinals where he lost to
Yoshihito Nishioka in a tight three-set match. At the
Adelaide International 2, he lost in the first round to compatriot and defending champion
Thanasi Kokkinakis. Playing as a wildcard at his home slam, the
Australian Open, he stunned eighth seed and world No. 9
Taylor Fritz, in the second round to advance to the third round for the third time at this event. He ended up losing in the third round to American rising star
Ben Shelton. As a result, his ranking moved back into the top 100 from No. 113 to No. 90. In February, Popyrin competed at the
Bahrain Ministry of Interior Challenger in Manama, Bahrain. Seeded second, he made it to the quarterfinals where he lost to eighth seed and eventual champion, Thanasi Kokkinakis. In
Dubai, he was defeated in the first round by qualifier
Pavel Kotov. In March, he competed at the
BNP Paribas Open. He fell in the final round of qualifying to
Taro Daniel. However, due to the withdrawal of
Kwon Soon-woo, Popyrin entered the main draw as a lucky loser. He lost in the second round to ninth seed and world No. 11
Hubert Hurkacz. At the
Arizona Classic, he reached the quarterfinals where he was defeated by eventual champion
Nuno Borges. In
Miami, he was eliminated from the tournament in the second round by 26th seed
Botic van de Zandschulp. Popyrin started his clay-court season at the
Grand Prix Hassan II. He lost in the second round to second seed and world No. 30,
Dan Evans. Getting past qualifying at the
Monte-Carlo Masters, he was defeated in the second round by
Nicolás Jarry. Playing at the first edition of the
Srpska Open, he upset fifth seed,
Tallon Griekspoor, in the first round. He lost in the second round to
Alex Molčan. In
Madrid, he was defeated in the first round by
Quentin Halys. Making it past qualifying on his debut at the
Italian Open, he earned his fifth Top 10 win of his career by upsetting world No. 10 Félix Auger-Aliassime, in the second round. Next, he defeated qualifier
Roman Safiullin in the third round to reach the fourth round for the first time at a Masters level. He lost his fourth-round match to world No. 7
Holger Rune, in a three setter that lasted three hours. At the
French Open, Popyrin lost in the first round to qualifier
Aslan Karatsev. In
Surbiton, he lost in the first round of the singles to
Luke Saville, but made the semi-finals of the doubles, partnering
Aleksandar Vukic. He then beat
Arthur Rinderknech in
Rosmalen, before losing to eventual champion
Tallon Griekspoor in the second round. He then qualified for
Queen's Club, before losing to
Jordan Thompson in the first round. In
Wimbledon, Popyrin lost in five sets to
Dominic Stricker in round one. Popyrin's next tournament was
Umag, where he defeated
Benjamin Bonzi, third seed
Sebastian Ofner, wildcard
Dino Prižmić, seventh seed
Matteo Arnaldi, and sixth seed
Stan Wawrinka in the final to win his second ATP Tour title. At the
Cincinnati Open, he reached the fourth round of a Masters for a second time in the season and in his career, after entering as a lucky loser and defeating another lucky loser
Daniel Altmaier and
Nicolás Jarry by walkover. Next he reached his first Masters quarterfinal defeating
Emil Ruusuvuori. As a result, he reached the top 40 in the rankings.
2024: Canadian Open title, Olympics debut At the
2024 Australian Open, he reached the second round but lost to world No. 1,
Novak Djokovic. At the
Qatar Open, he reached the semi-finals defeating wildcard
Abdullah Shelbayh, qualifier
Hugo Grenier and fourth seed
Alexander Bublik. He lost to eventual champion and fourth seed
Karen Khachanov. Popyrin notably defeated the defending champion and sixth seed
Andrey Rublev in the second round of the
2024 Monte-Carlo Masters, taking it in straight sets, his second career top 10 win on clay. Together with
Alex de Minaur, they became the first Australians to reach the third round in Monte Carlo since
Lleyton Hewitt and
Wayne Arthurs in 2004. The Australian made his debut at the
2024 Summer Olympics, France, where he reached the third round with wins over
Nicolás Jarry and
Stan Wawrinka. He lost to reigning Olympic champion
Alexander Zverev. Ranked No. 62, Popyrin won his first ATP 1000 title at the
2024 Canadian Open, on his debut at this Masters, replacing a withdrawn player to enter the main draw automatically. He defeated
Tomáš Macháč and upset five top 20 players en route, eleventh seed
Ben Shelton, seventh seed
Grigor Dimitrov, saving three match points, fourth seed Hubert Hurkacz,
Sebastian Korda and fifth seed Andrey Rublev in the final. As a result, Popyrin achieved a career high in the top 25 at world No. 23 in the singles rankings on 12 August 2024. He became the third Australian player to defeat at least two top 10 players in a Masters 1000 in the same season after Lleyton Hewitt and Nick Kyrgios. He became the lowest ranked finalist in men's singles since
Harel Levy in 2000 who reached the final as a qualifier. He was just the eighth Aussie man to make an ATP 1000 final, and the fourth to win a title, joining Rafter, Philippoussis and Hewitt, while Kyrgios, De Minaur, Jason Stoltenberg and Todd Woodbridge, had all made the finals. At the
US Open, Popyrin reached the fourth round of a Grand Slam for the first time with an upset over defending champion Novak Djokovic in four sets. This marked the first time an Australian has beaten Djokovic at a Grand Slam since
Lleyton Hewitt at the
2006 US Open. Popyrin lost in four sets to 20th seed
Francis Tiafoe.
2025: Monte-Carlo and Toronto quarterfinals Popyrin had a rocky start to the year, losing to
Matteo Arnaldi in
Brisbane,
Corentin Moutet at the
Australian Open,
Jiří Lehečka in
Rotterdam, despite being seeded 25th, and
Jack Draper in
Doha. He finally picked up his first win of the season against
Hady Habib in
Dubai, but lost to
Marin Čilić in the second round. He reached the third round of
Indian Wells, beating
Zizou Bergs before losing to
Marcos Giron, and got upset in the second round of
Miami by
Roman Safiullin. Popyrin was more successful on clay. He reached his third Masters 1000 quarterfinal in
Monte-Carlo, beating
Ugo Humbert,
Frances Tiafoe and upsetting world No. 7
Casper Ruud before losing to
Alejandro Davidovich Fokina. However, he was subsequently upset in the second round of
Madrid by
Alexander Bublik, and the first round of the
Aix-en-Province Challenger to
Stan Wawrinka. He defeated qualifier
Carlos Taberner in
Rome before losing to
Daniil Medvedev in the third round. He finished off his clay season strongly, reaching the quarterfinals of
Geneva and having his best performance at the
French Open, where he reached the fourth round. On the grass courts, Popyrin only picked up one win, in
Queen's Club against
Aleksandar Vukic. He was subsequently upset in the first round of
Wimbledon after losing to
Arthur Fery in 4 sets. As the defending champion, Popyrin reached his fourth Masters 1000 quarterfinal in
Toronto, where he beat wildcard
Nicolas Arseneault, 10th seed
Daniil Medvedev and 5th seed and world No. 9
Holger Rune. He lost in 3 sets in the quarterfinals to
Alexander Zverev. ==National representation==