On the evening of 15 July 1500, at the top of the steps before the entrance to
St. Peter's Basilica, Alfonso was attacked by hired killers and stabbed in the head, right arm, and leg. When the assassins attempted to take Alfonso with them, his own guards put them to flight. Alfonso was residing in the palace of Santa Maria in Portico, but so desperate was his condition that he was taken to the chamber of the Borgia Tower where he was cared for by his doctors from Naples, his sister, Sancha, and his wife, Lucrezia. On the night of 18 August, as Alfonso was still recovering from his wounds,
Micheletto Corella and a group of armed men entered his room and strangled him in his bed until he was dead. In the political context of a French campaign against Naples, Cesare Borgia is the most likely candidate being behind the assassination. In his own defence, Cesare argued that Alfonso had attempted to kill him with a crossbow shot as he walked in the garden, but not many believed him. Alfonso, given his sympathy for the
Colonna family, had enemies at Rome amongst the
Orsini too, and Pastor suggested that they were behind the killing, though most evidence points to Cesare Borgia. Also accused was Alfonso's uncle Giovan Maria Gazzera, mysteriously killed in Rome shortly after, and even Pope Alexander VI, because Alfonso, in May 1500, showed his discontent with the Pope's decision to nullify the marriage between Alfonso's aunt
Beatrice of Naples and
Vladislaus II of Hungary. Two years later Lucrezia was given in marriage to
Alfonso I d'Este. Lucrezia was obliged to simulate the appearance of a virgin spouse in order to marry d'Este. Accordingly, she was forced to leave
Rodrigo of Aragon, her only child by Alfonso of Aragon, behind forever. Rodrigo Borgia of Aragon died of a disease in
Bari at the age of 12. ==Ancestors==