Lowe began her career in surreal experimental theatre shows including
City Haunts,
Snowbound and
Progress in Flying Machines co-devising and performing along with colleagues such as
Robert Webb and
David Mitchell. Lowe worked under the directorship of
Paul King, who has since directed her in
The Mighty Boosh and ''
Garth Marenghi's Darkplace. In 2001, she won an award for performing in the sequel to Fright Knight
, Garth Marenghi's Netherhead'', Lowe appeared in the action comedy film
Hot Fuzz, Lowe had a role in the
Edgar Wright-directed film ''
The World's End''. On
BBC Radio 4, she has written three series of ''Alice's Wunderland'' a dark, surreal comedy. In 2016, she made her directorial debut on the critically acclaimed
Prevenge, which she directed while pregnant. In 2018, Lowe appeared as Dr Haynes in Netflix's first adult-targeted interactive film,
Black Mirror: Bandersnatch. In February 2021, Lowe's film
Timestalker was announced. The film will "chronicle one woman's unrequited love across several centuries [...] from 1680s Western Scotland to the apocalyptic 22nd Century." Lowe stated that "[t]his film is my homage to the most romantic epics. Lavish, lush and overflowing with emotion." Filming began in late 2022 and it was released October 2024. ==Personal life==