From 1986 to 1992, during his tenure as commissioner for health in Anambra State, Nwosu spearheaded significant advancements in public health initiatives, infrastructure, and healthcare services. He was a member of the Presidential Advisory Committee on Health and later served as special adviser to President
Olusegun Obasanjo on political matters. In February 2001, he was appointed minister of health, where he led efforts to combat infectious diseases and implement healthcare reforms, including the establishment of the National Health Insurance Scheme (NHIS). == Personal life ==