Television In the late 1980s, she was hired to perform with Second City's touring company. It was there she met
Paul Dinello and
Stephen Colbert, with whom she often collaborated later in her career. She and Dinello did not get along with Colbert at first, but they became close friends while touring together, discovering that they shared a similar comic sensibility. Sedaris left Second City in 1993, and moved to
New York City. Beginning in 1999 Sedaris played Jerri Blank, a middle-aged woman who goes back to high school in the Comedy Central comedy series
Strangers with Candy. The series, which she co-wrote with Dinello and Colbert, was based on Sedaris's impression of 1970s-era
motivational speaker Florrie Fisher. The show ran for three seasons. In 2005, a
film adaptation was released, acting as a
prequel to the series. Sedaris went on to make numerous guest appearances on television programs, including
Just Shoot Me! (2001),
Sex and the City (2002–2003),
Monk (2002–2003),
Wonder Showzen (2005),
My Name Is Earl (2006),
Sesame Street (2006),
Rescue Me (2007),
The Closer (2009),
The New Adventures of Old Christine (2009),
The Middle (2010),
Raising Hope (2011–2014), and
The Good Wife (2012). She also hosted the series
Film Fanatic on
Trio. Sedaris's talk show appearances include
Late Show with David Letterman,
The Late Show with Stephen Colbert, ''
Late Night with Conan O'Brien, Jimmy Kimmel Live!, The Late Late Show with Craig Ferguson, The Daily Show, The Colbert Report, Late Night with Jimmy Fallon, and WTF with Marc Maron. During an appearance on Chelsea Lately'', she gave host
Chelsea Handler a presentation on vaginal hygiene using a plush vagina created by fashion designer
Todd Oldham. at the 2006
Texas Book Festival In 2008, Sedaris starred as Principal Abby Hofman in the
Nickelodeon television film
Gym Teacher: The Movie, which was directed by her
Strangers with Candy co-star and frequent collaborator
Paul Dinello. In early 2010, she had a supporting character in the Canadian comedy series
The Drunk and On Drugs Happy Fun Time Hour. Later in 2010 she appeared alongside Paul Dinello in the episode "Mummified Hand", of the
Discovery/
Science Channel documentary series
Oddities. In 2011, she appeared in a series of commercials for
Downy (
Lenor UK) Unstoppables, a
fabric softener product.
Grey Global Group designed the commercials as "kicking the old 'mom' image with spots featuring 'laundry expert' (and accomplished lifestyle guru) Amy Sedaris". In 2013, she replaced
Kristen Schaal as the sex-crazed Hurshe Heartshe, in the second season of the
Adult Swim comedy series
The Heart, She Holler. She also appeared in third and final season. That same year, Sedaris appeared in a major recurring role in the
Amazon Prime Video political satire series
Alpha House, which was written by
Doonesbury creator
Garry Trudeau. Sedaris played Louise Laffer, the Mormon wife of Nevada Senator Louis Laffer who lives with three other Republican senators in a town house on Capitol Hill. Sedaris later had a recurring role as Pam in the
Comedy Central sitcom
Broad City (2014–2019), as Rita in the
Hulu dark comedy series
Difficult People (2015–2017). From 2015 to 2020, she portrayed Mimi Kanasis in the
Netflix comedy series
Unbreakable Kimmy Schmidt, for which she earned a nomination for the
Gold Derby Award for Best Comedy Guest Actress. In 2016, Sedaris appeared in the
tragicomedy series
Horace and Pete, as a character named Mara looking for a job at Horace and Pete's. She also co-starred with
Chris Elliott in the
Sony Crackle family comedy series
Thanksgiving. In 2017, Sedaris created the
TruTV surreal comedy series
At Home with Amy Sedaris, which she also wrote and executive produced. The series focused on the comedian's love of entertaining, crafts, and cooking. She played numerous characters, including herself, Patty Hogg, Ronnie Vino, and Nutmeg. The series was met with critical acclaim upon its premiere, garnering two consecutive nominations for the
Primetime Emmy Award for Outstanding Variety Sketch Series, and ran for three seasons. Sedaris had a starring role as Janice Delongpre, a dispatch officer, in the
CBS All Access comedy series
No Activity from 2017 to 2019. She had guest-starring roles as Cathy in the
HBO comedy-drama series
Divorce (2018).
Voice Sedaris has voiced commercials for the discount hair salon chain
Supercuts and was
WordGirl character Miss Davis for two seasons. She also voiced the Bandit Princess in
Adventure Time. She narrated the
PBS special ''Make 'Em Laugh: The Funny Business of America'', a six-hour documentary on comedians and comedy in American history. In film, Sedaris voiced Foxy Loxy in the science fiction comedy
Chicken Little (2005), Cinderella in the animated fantasy comedy
Shrek the Third (2007), Gravity in the family comedy
Space Buddies (2009), Jill in the adventure comedy
Puss in Boots (2011), Betty in the fantasy comedy
Super Buddies (2013), and Aunt Ida in the English dub of the
Academy Award-nominated comedy drama
My Life as a Courgette (2016). She voiced the role of Audrey Temple in two seasons of the podcast
Homecoming (2016–2017). The series was later adapted into a
series of the same name, starring
Julia Roberts. Sedaris' character was portrayed in the series by
Hong Chau. Sedaris voiced characters in numerous animated series. From 2014 to 2020, she provided the voice for
Princess Carolyn in the Netflix adult animated comedy series
BoJack Horseman, a role which some critics consider her best work. She also voiced various characters in the
Fox adult comedy series
American Dad! (2009–2012), Ma Angler in the
Nickelodeon children's comedy series
SpongeBob SquarePants (2011–2019), Lydia / Mina Loveberry in the
Disney Channel action fantasy series
Star vs. the Forces of Evil (2016–2019), the Zircons in the
Cartoon Network coming-of-age series
Steven Universe (2017), and Samantha in the Netflix adult comedy series
F is for Family (2020). In 2019, Sedaris voiced a Guinea Fowl in the musical drama film
The Lion King (2019), which is a
photorealistic animated remake of Disney's
1994 film of the same name. In 2022, Sedaris voiced Suzanne in Meet Cute's holiday rom-com audio series,
Christmasuzannukkah. "I've always loved holiday movies. They're like comfort food and they never get old," said Sedaris. "
Christmasuzannukkah really brings together the joy, drama and heart of the season, and it was so much fun to be able to do this in a podcast form."
Film Throughout her career, Sedaris had supporting roles in a number of feature films. She appeared in the romantic comedy
Maid in Manhattan (2002), the musical comedy
School of Rock (2003), the Christmas comedy
Elf (2003), and the fantasy comedy
Bewitched (2005). Her first leading film role came in the 2005 film adaptation
Strangers with Candy, which she also co-wrote. She followed this with supporting roles in the comedy-drama film
Full Grown Men (2006), the drama film
Snow Angels (2007), and the ensemble comedy film
Old Dogs (2009). Sedaris had a large role in the comedy film
The Best and the Brightest, which was released in 2010. She went on to star in the horror comedy film ''
Jennifer's Body (2009), the comedy-drama film Chef (2014), the supernatural comedy film Ghost Team (2016), the mystery comedy film Handsome (2017), and the comedy film Save Yourselves! (2020). She also played the heart surgeon Dr. Ladenheim in Clerks III (2022) and also plays a sentient book, Jaunty, in Smurfs'' (2025). Sedaris will next reunite with Dinello for a remake of
Roger Corman's
science fiction film
The Wasp Woman (1959). Dinello is set to write and direct the film with Sedaris starring.
Writing In 2003, Sedaris co-authored the text-and-picture novel
Wigfield alongside collaborators Paul Dinello and Stephen Colbert. Sedaris has contributed several articles for
The Believer magazine since 2005. In a 2006 interview with the magazine, she answered part of a Q&A section with, "TURN-OFFS: The beach, having to pay for things, racist people, Orientals." In 2006, Sedaris released
I Like You: Hospitality Under the Influence, a guide to entertaining, which stayed on the
New York Times bestseller list for more than 12 weeks. In 2007, she was working with Dinello on a show for
HBO, loosely based on the book, but the project never came to fruition. In 2010, she released the crafting book
Simple Times: Crafts for Poor People!. While promoting her book on
Late Night with David Letterman in October 2010, she demonstrated how the cover can easily be made into a hat.
Theater Amy has co-written several plays with her brother David, credited only as "The Talent Family":
Stump the Host (1993),
Stitches (1994),
One Woman Shoe (1995),
Incident at Cobblers Knob (1997), and
The Little Frieda Mysteries (1997). The pair's
The Book of Liz (2002) focused on
cheese balls as a metaphor for "the cliches we all live by", according to
Ben Brantley. She played a role as the Stage Manager in
Paul Rudnick's play
The Most Fabulous Story Ever Told (1998) and as Froggy in
Douglas Carter Beane's play
The Country Club (1998), the latter of which earned her a nomination for the
Drama Desk Award for Outstanding Featured Actress in a Play. She had a role in
David Lindsay-Abaire's play
Wonder of the World and the stage adaptation of her book
Wigfield (2003), alongside
Paul Dinello and
Stephen Colbert.
Other work In support of
People for the Ethical Treatment of Animals (PETA)'s anti-fur campaign, Sedaris appeared as her
Strangers with Candy character in an ad that reads, "When you wear fur, people laugh
at you, not
with you." In 2007, Sedaris was featured in
Dolly Parton's first mainstream
country music video in fourteen years, "
Better Get to Livin'. She was the emcee for
Microsoft's 2010 annual employee meeting in
Seattle on September 28, 2010. ==Personal life==