In 1993, Weiss was ordained as a rabbi at HUC-JIR in New York. In 2000, Weiss joined the faculty of HUC-JIR in New York, as an Associate Professor of Bible. She earned a
PhD from the
University of Pennsylvania in 2004, in the department of Near Eastern Studies and Civilizations. She was later a visiting professor at the University of Pennsylvania. In 2018, Weiss was appointed HUC-JIR's Jack, Joseph and Morton Mandel
Provost, serving through the
COVID-19 pandemic until June 2025. She served as Head of Seminary and Rabbinical School Director at HUC-JIR. In 1993, Weiss was an editor of the publication "Shalom/Salaam: A Resource for Jewish-Muslim Dialogue". In 2006, Weiss published the book
Figurative Language in Biblical Prose Narrative: Metaphor in the Book of Samuel (Supplements to Vetus Testamentum). Weiss is best known as the associate editor of
The Torah: A Women’s Commentary, which won the 2008 Jewish Book of the Year Award from the
Jewish Book Council. The book consists of five forms of biblical
exegesis, by hundreds of women authors. Weiss previewed drafts of the book to Jewish congregations across the United States during the two years preceding its publication. In addition to the valuable perspectives offered by and to women, Weiss would often have to explain the book's essays and commentaries were also important to men as a body of work falling within the Jewish tradition of biblical exegesis and commentaries.
United States Senator Elissa Slotkin was sworn in on the book. Weiss gave the 2012 Goodman Lecture at
St. Catherine's University on "Ancient Words, New Voices: The Story of The Torah—A Women’s Commentary". Weiss frequently was asked to serve as a scholar-in-residence. Among other times serving as a scholar-in-residence, in 2006, she was a scholar-in-residence for Temple Israel in
West Palm Beach, Florida; in 2007, she was scholar-in-residence for Temple Beth El in
Closter, New Jersey; in 2012, Weiss was a Goldstein/Leibson scholar-in-residence in
Louisville, Kentucky; and in 2024, she was scholar-in-residence at
Congregation Beth Israel, in
Houston. In 2016–17, and again in 2020–21, Weiss initiated and led the nonpartisan interfaith American Values, Religious Voices campaign, involving the writing of 100 350-word letters by faith leaders directed to political leaders in the United States. These letters collectively have been published in two books. The
Center for American Progress named Weiss as a faith leader to watch in 2018 because of her efforts to highlight the voices of a diverse set of religious scholars. The 2022 art exhibit “Holy Sparks”, shown among other places at the
Dr. Bernard Heller Museum, featured art about twenty-four female rabbis who were firsts in some way; Debbie Teicholz Guedalia created the artwork about Weiss that was in that exhibit. == Legacy ==