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Angela Hartley Brodie

Angela Hartley Brodie was a British biochemist who pioneered development of steroidal aromatase inhibitors in cancer research. Born in Lancashire, Brodie studied chemical pathology to a doctoral level in Sheffield and was awarded a fellowship sponsored by National Institutes of Health. After 17 years of working in Shrewsbury, Massachusetts on oral contraceptives with Harry Brodie, whom she married, she switched her research focus to the effects of the oestrogen-producing enzyme, aromatase, on breast cancer.

Early life and education
Brodie was born Angela Hartley on 28 September 1934 in Oldham, Lancashire, England. Her father, Herbert Hartley, was an industrial chemist working in polyurethanes Brodie was educated at a Quaker boarding school before studying at University of Sheffield, where she earned a degree in biochemistry. ==Career, 1962–2016==
Career, 1962–2016
As a result of her doctorate, she was awarded a National Institutes of Health sponsored, 1-year post-doctoral training fellowship, at Clark University and the Worcester Foundation for Experimental Biology in Shrewsbury, Massachusetts. She researched at Worcester Foundation between 1962 In 1979, she moved to Maryland, encouraged by Cornelia Channing to join the University of Maryland School of Medicine, first as an associate professor. and proved to be a significant improvement on tamoxifen, the standard cancer drug used to treat oestrogen receptor-positive breast cancer in postmenopausal women. The drug was first marketed in 1994. In 2005, Brodie received the prestigious Kettering Prize, the first woman to receive the award, though she did not know she had been nominated. At the time, she was on the editorial board of multiple professional journals, reviewed grant applications for the NIH, had published over 200 papers in peer-reviewed journals, and was a member of the integration for the US Army Department of Defense Army Breast Cancer Program. In 2016, she retired from the University of Maryland. ==Personal life and death==
Personal life and death
According to co workers Brodie "was kind and generous but not weak. She knew how to stand up for herself and push her own agenda." She "had a steely determination combined with a positive can-do attitude." In 2006, her son John, died from accidental drowning. She never intended to retire, and collaborated with Vincent Njar on aromatase inhibitors in prostate cancer for the rest of her life. She died on 7 June 2017 at the age of 82 at her home in Fulton, Maryland, from complications due to Parkinson's disease. ==Awards==
Awards
• 1998 Pharmacia and Upjohn International Award for Excellence in Published Clinical Research • 2005 Charles F. Kettering Prize from the General Motors Cancer Research Awards • 2006 Dorothy P. Landon-American Association for Cancer Research Prize for Translational Cancer Research • 2006 Health Care Heroes Award sponsored by The Daily Record newspaper. • 2007 University of Massachusetts Medical School presented Gregory Pincus Medal • 2010 Jacob Heskel Gabbay Award in Biotechnology and Medicine • 2012 Pharmacia-ASPET Award for Experimental Therapeutics • 2023 National Inventors Hall of Fame ==Further reading==
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