Everton Due to Manchester United's lack of a senior women's team, Moorhouse moved to
Everton to begin her senior career a year later. She did not make an appearance for Everton in two seasons behind
Rachel Brown and
Danielle Hill, with
Lizzie Durack and
Megan Walsh joining in her second season.
Durham In 2014, Moorhouse joined newly formed
WSL 2 club
Durham. She spent two seasons with the club, making a total of 15 appearances.
Doncaster Rovers Belles In 2016, Moorhouse made the jump up to the
WSL 1 with
Doncaster Rovers Belles to compete for playing time with
Nicola Hobbs. She made four appearances including on the last day of the
2016 season when already-relegated Doncaster, having lost all 15 of the previous league games, beat
Reading 1–0.
Arsenal Ahead of the 2017
FA WSL Spring Series, Moorhouse moved to
Arsenal. She made her debut on 20 May 2017, in the final game of the Spring Series, a 4–2 victory over
Birmingham City as Arsenal finished third. During the full
2017–18 season, she made four league appearances behind
Sari van Veenendaal but was used as a cup keeper in the early stages as both the
FA Cup and
League Cup. Arsenal reached the final of both competitions with Moorhouse an unused substitute behind van Veenendaal on both occasions as Arsenal won the League Cup but lost the FA Cup.
West Ham United In July 2018, Moorhouse left Arsenal in search of more first-team opportunities with newly promoted FA WSL team
West Ham United. She split playing time with
Rebecca Spencer, each making 10 league starts each although Moorhouse was named the starter in all five FA Cup games as the team reached the
final for the first time before losing 3–0 to
Manchester City in front of 43,264 at
Wembley Stadium. Although Spencer left in the
2019–20 offseason, Moorhouse fell into a backup role behind summer recruit
Courtney Brosnan, playing four league games and a further four League Cup games before leaving at the end of the campaign upon the expiration of her contract.
Bordeaux In June 2020, Moorhouse signed as a free agent with French
Division 1 Féminine team
Bordeaux who had lost starter
Erin Nayler that summer. The move reunited her with former Arsenal coach
Pedro Martínez Losa. She was the club's first choice keeper, playing in 20 of 22 league games. She conceded 15 goals and kept 10 clean sheets as Bordeaux finished third behind powerhouses Lyon and Paris Saint-Germain, qualifying the team for the
UEFA Women's Champions League for the first time in their history. She became backup behind summer recruit
Mylène Chavas during the season before leaving in January 2022, citing frustrations with changes in Bordeaux's style of play following the appointment of
Patrice Lair.
Orlando Pride In January 2022, Moorhouse signed with
NWSL team
Orlando Pride ahead of the
2022 season. Orlando used
allocation money to sign Moorhouse from Bordeaux having lost starter
Ashlyn Harris in the offseason. She was second choice behind
Erin McLeod but made her debut on 30 March 2022, in a 1–0 defeat to
Gotham FC in the
2022 NWSL Challenge Cup. In McLeod's absence, Moorhouse started a further two games, 4–1 and 4–2 defeats to
Washington Spirit and
North Carolina Courage before being benched in favour of
Kaylie Collins to make her professional debut in the final game of the group stage with Orlando already eliminated. Moorhouse also featured in two NWSL regular season matches during the 2022 campaign. In total she made five appearances in her debut season, all defeats, as she did not keep a clean sheet and conceded 13 goals. When McLeod left after the 2022 season, Moorhouse became the team's starter for the
2023 season. She made a club-record 12 saves in the Pride's season opener on 26 March 2023 against
Portland Thorns FC, as Orlando lost 4–0 loss. After two defeats to open the season, new permanent head coach
Seb Hines started Collins in the third game before handing a club debut to offseason signing
Carly Nelson in the Challenge Cup. After three games out, Moorhouse returned to the starting lineup in the team's first victory of the season, beating
San Diego Wave FC 3–1. It marked her first win as an Orlando Pride player. In her ninth appearance, Moorhouse kept her first clean sheet for Orlando in a 1–0 win over
Racing Louisville FC. In January 2024, Moorhouse acquired a
U.S. green card meaning she would no longer occupy an international roster spot. During the 2024 season, Moorhouse played every regular season game and set a new NWSL record for clean sheets in a single season with 13, beating
Adrianna Franch's 11 shutouts set with Portland Thorns in 2017. The team won the
NWSL Shield, and also set records for a new NWSL regular season unbeaten streak of 24 matches and most wins in an NWSL season with 18. ==International career==