She was wed in 1656, at the kirk of
Corstorphine near
Edinburgh, to
William Douglas, 1st Earl of Selkirk, a younger son of
William Douglas, 1st Marquess of Douglas. Selkirk was created Duke of Hamilton for his lifetime, included the subsidiary titles pertaining to the Dukedom
jure uxoris, and in 1660 he assumed the surname Hamilton. Between 1657 and 1673, the couple produced 13 children: • Lady Mary Hamilton (1657–1666) •
James Hamilton, 4th Duke of Hamilton (1658–1712), until 1698 he was styled as Earl of Arran • Lord William Hamilton (1659–1681) • Lady Anna Hamilton (1661–1663) • Lady Catherine Hamilton (1662–1707), married
John Murray, 1st Duke of Atholl •
Lord Charles Hamilton (1664–1739), later 2nd
Earl of Selkirk •
Lord John Hamilton (1665–1744), later 1st
Earl of Ruglen and 3rd Earl of Selkirk • Field Marshal
Lord George Hamilton (1666–1737), later 1st
Earl of Orkney • Lady Susan Hamilton, married firstly
John Cochrane, 2nd Earl of Dundonald; married secondly John Hay, 3rd
Marquess of Tweeddale • Lady Margaret Hamilton (1668–1731), married
James Maule, 4th Earl of Panmure • Lady Anna Hamilton (b. 1669), died in infancy •
Lord Basil Hamilton (1671–1701) •
Lord Archibald Hamilton (1673–1754) James, Earl of Arran's father died in 1694, and in July 1698 his mother resigned all her titles into the hand of King William, who regranted them to Arran a month later in a charter signed at
Het Loo, Netherlands. He was conferred with the titles: Duke of Hamilton, Marquess of Clydesdale, Earl of Arran, Earl of Lanark, Earl of Cambridge, Lord Aven, Polmont, Machansyre, and Innerdale. This regrant of title was presumably because of the loyalty of Arran's parents to the King, as his own affection to the House of Orange was questionable due to his suspected
Jacobitism. The Duchess died at Hamilton on 17 October 1716, and is buried there, in the Bent Cemetery. ==Building works==