Clough was born at
Liverpool,
Lancashire, the daughter of cotton merchant James Butler Clough and Anne (née Perfect). James Butler Clough was a younger son of a landed gentry family that had been living at
Plas Clough in
Denbighshire since 1567. Anne's brother was
Arthur Hugh Clough, the poet and assistant to
Florence Nightingale. When two years old she was taken with the rest of the family to
Charleston, South Carolina. It was not till 1836 that she returned to Britain. Anne's own education was entirely at home, as was common for middle and upper-class women of the time. She worked as a volunteer in a Liverpool
charity school and became determined to run a school of her own. When her father became bankrupt in 1841, she took the opportunity to set up a small day school. This enabled her to contribute financially, while fulfilling her interest in education. She subsequently worked at the
Borough Road School and the
Home and Colonial School Society. After her father's death, she moved to
Ambleside, setting up a school for local children and boarders, Eller How. On the death of her brother Arthur, she moved to Surrey, to support her sister-in-law Blanche Clough in bringing up their three small children. The youngest daughter,
Blanche Athena Clough, would follow in her aunt's footsteps and herself become a notable educationalist. Keenly interested in the education of women, she made friends with
Emily Davies,
Barbara Bodichon,
Frances Buss and others. She gave evidence to a Royal Commission on secondary schooling, based on her own teaching experience. After helping to found the
North of England Council for Promoting the Higher Education of Women, she acted as its secretary from 1867 to 1870 and as its president from 1873 to 1874. Her scheme for peripatetic lecturers was the germ of the University Extension Movement. ==The foundation of Newnham College==