First presidency Ciampi was appointed the
president of the College of the Holy Cross on 28 August 1851, at the age of 35. When he took office, Ciampi's main objectives were to decrease the college's high debt and to increase discipline among the Jesuits. He became a mentor to the school's 10 Jesuit
brothers, Nonetheless, Ciampi managed to reduce the debt, and was widely praised by both the Maryland
provincial superior, Joseph Aschwanden, and the Holy Cross Jesuits for his financial acumen and piety. On 14 July 1852, less than a year after Ciampi's appointment, a serious fire struck the college building, Fenwick Hall. Despite the efforts of the
fire department and local citizens of Worcester to haul water nearly a quarter of a mile up the hill from the river, the entire building was destroyed, except for the east wing and the contents of the library, which were rescued from the fire. Student dormitories, including all their possessions, were lost, and the uninsured college, which had no savings, faced a cost of $50,000 (equivalent to approximately $ in ). The fire may have begun on the third floor by a professor who was burning old examination papers. Neighbors offered lodging for the night to the faculty and students, who were left with nowhere to live. The following day, all the students were sent home. Within three days, Ciampi began planning to rebuild the college. However, Aschwanden, in a letter to Roothaan, vowed never to rebuild it due to the school's debt, its location outside of a major city, its competition for resources with the newly opened
Loyola College in
Baltimore, and the susceptibility of the surviving wing to another fire. He urged Ciampi to accept a new position in
Philadelphia. Ciampi wrote to Roothaan directly, requesting not to be reassigned and in support of rebuilding the college. After a new provincial superior,
Charles Stonestreet, was appointed, Roothaan decided to allow Holy Cross to be rebuilt. Bishop
John Bernard Fitzpatrick of Boston called for Catholics to donate to the reconstruction. Ciampi raised money, increased tuition, and cut expenses, declining to heat the building into autumn, but faced hesitation from Stonestreet. A new and larger building was opened on 3 October 1853. Enrollment was slow to rebound after reopening. On 13 August 1854, he was succeeded as president by
Peter J. Blenkinsop.
Second presidency Ciampi was selected to resume the presidency after Blenkinsop, taking office on 15 August 1857. Ciampi was unable to restrain several Jesuit
scholastics who
corporally punished and injured students, against Ciampi's orders and the Jesuit's rules. In December 1857, Ciampi had to send the students home early to avoid the cost of housing them. Nonetheless, by the end of Ciampi's tenure, the financial condition of the college improved. By 1859, he and Bishop Fitzpatrick ultimately persuaded the new superior general
Peter Jan Beckx not to close the college. Meanwhile, some at Holy Cross disliked Ciampi's "Roman manners" and criticized his
pedagogy as overbearing. They also criticized his frequent absences from campus and his friendly relations with a woman whom he
converted to Catholicism. Beckx wrote to Ciampi that while his absences were for good causes, he had to be present on campus. By 1858, even though Ciampi had ceased his extended departures from campus, the new provincial superior,
Burchard Villiger, wanted Beckx to remove Ciampi. However, Beckx declined to do so because many viewed Ciampi as essential to the continued improvement of Holy Cross. Beckx appointed a
visitor to the entire Jesuit province in 1859, who praised Ciampi's work. Ciampi reformed the curriculum to instruct students in the
liberal arts, patterned on the
Ratio Studiorum. He also eliminated the
student uniform due to the inability of some families to afford them. On 15 August 1861, Ciampi was succeeded by
James Clark.
Third presidency Ciampi was appointed the president of the College of the Holy Cross for a third time on 28 August 1869, to succeed
Robert W. Brady. At the same time, he again significantly reduced the college's debt. Ciampi again slightly revised the curriculum. While Ciampi was considered a successful administrator, == Loyola College in Maryland ==