J. J. Lister was deeply interested in natural history, and realized that the
microscopes available in the early 19th century did not provide adequate
resolution to reveal the structure of
plant cells and
animal cells in sufficient detail. He therefore set out to improve the design of the
objective lens, improving upon the
achromatic lens first designed by
Chester Moore Hall and
John Dolland in the 18th century, and altering the spacing of the lens elements such that the resulting
compound lens not only provided better correction for
chromatic aberration, but minimized
spherical aberration as well. He performed this work in his spare time, while fully engaged in his wine business. He began this work in 1824, and by 1826 he had commissioned an improved
microscope stand to be made by the instrument-making firm of
William Tulley. The stand was made by an employee of Tulley, James Smith, and is preserved in the
Wellcome Institute. Smith set up on his own in 1837, later taking on Richard Beck, a nephew of Lister, as an apprentice finally becoming a partner in 1847 when the company was renamed Smith & Beck. Lister published his work in 1830 in a paper entitled "
On Some Properties in Achromatic Object-Glasses Applicable to the Improvement of the Microscope" submitted to the Royal Society, and collaborated with Smith and with Andrew Ross, who had established what was to become one of the finest microscope manufacturers in 1832. Lister's law of aplanatic foci remained the underlying principle of microscopic science. He had a large circle of scientific contacts, including
Airy,
Herschel and fellow Quaker Dr
Thomas Hodgkin, with whom he discussed microscopic observations including those of
red blood cells, leading to the identification of '
Hodgkin's disease’. He was elected a Fellow of the
Royal Society in 1832. His interest continued, writing a paper in 1843, entitled 'On the Limit to Defining Power in Vision with the Unassisted Eye, the
Telescope and the
Microscope’. It was never published, but years later it was presented by his son Lord Lister to the
Royal Microscopical Society, and seen to have anticipated many of the later discoveries made by
Ernst Abbe and others. ==Old age==