Acting Loberti’s first acting role was as the lead character of Marie-Laure Leblanc in
Netflix's adaptation of the 2014 novel
All the Light We Cannot See. It was also her first audition. Her performance has been universally praised by critics, described as "graceful and affecting", "luminous", "resonant, [and] captivating", and a "radiant…good and pure presence that grounds the series' sense of jeopardy". Her co-star
Mark Ruffalo referred to her as "a revelation". Loberti, who has a form of the genetic eye condition
achromatopsia, landed the part after a global search for an actor who was blind or had low-vision. A fan of the book, she auditioned after learning about the search from a childhood teacher. Despite no acting training, Loberti beat out thousands of submissions to secure the role three weeks after she sent in her self tape. Director
Shawn Levy stated of Loberti: "I didn't know what she had acted in, I didn't know what her training was, all I knew is that there was a combination of intelligence, which was extremely self-evident, and a luminous quality on camera… I later found out that not only was she new to acting—she had never even auditioned before." She received a Rising Star Award at the 2023
Toronto International Film Festival and an
Entertainment Weekly Breaking Big Award at the 2023
SCAD Savannah Film Festival. She was nominated for Best Breakthrough Performance at the 2024
Film Independent Spirit Awards. In September 2023, it was announced that Loberti would serve as the new face of the beauty and skincare brand
L'Occitane en Provence. In November 2023, it was announced that she would narrate a new audiobook version of
Jules Verne's
Twenty Thousand Leagues Under the Sea. ln 2024, she appeared in the
television adaptation of
The Spiderwick Chronicles as the magical fencing maestro Valentina and on
Grey’s Anatomy as Vida Madeira. Through social media in early 2025, she reported her eyesight has been largely corrected. She stated that, because of this, she will no longer be portraying characters who were blind or have low vision in any of her future acting projects, but that she is passionate about continuing her advocacy for that community.
Writing Loberti’s first book, a children’s picture book called
I Am Ingrid, will be published by
Scholastic in October of 2025. She has also stated that she authored a middle grade fantasy novel alongside her best friend, which has yet to have a publication date. == Activism ==