During the reign of the
Artaxerxes II, Autophradates captured
Artabazus, the
satrap of
Lydia and
Ionia who had revolted against the Persian king, and made him his prisoner, but afterwards was forced to set him free. Autophradates was also directed by Artaxerxes to put down the rebellion of the satrap of
Cappadocia Datames. He went with a large army, but was obliged to retreat with heavy loss. Autophradates later joined the
Revolt of the Satraps.
Resistance to Alexander the Great Autophradates participated to the Achaemenid resistance against the campaigns of
Alexander the Great in
Asia Minor. Together with
Pharnabazus III he supported militarily and financial the king of
Sparta Agis III who was organizing resistance against the Macedonians. After the death of the Persian admiral,
Memnon, in 333 BC, Autophradates and
Pharnabazus III, satrap of neighbouring
Hellespontine Phrygia, undertook the command of the fleet, and reduced
Mytilene, the siege of which had been begun by Memnon. Pharnabazus now sailed with his prisoners to
Lycia, and Autophradates attacked the other islands in the
Aegean Sea which supported
Alexander the Great. But Pharnabazus soon after joined Autophradates again, and both sailed against
Tenedos, which was induced by fear to surrender to the Persians. ==Tomb of Payava==