Pre-Islamic era The Banu Makhzum were a major clan of the larger
Quraysh tribal grouping which dominated
Mecca. Though in Arab genealogical tradition, there are some twenty branches descended from the progenitor Umar ibn Makhzum, the line of
al-Mughira ibn Abd Allah ibn Umar ibn Makhzum emerged as the principal family of the Banu Makhzum.
Early Islamic era The Banu Makhzum were among the foremost opponents of the
Islamic prophet
Muhammad in Mecca in the early 7th century. One of their chieftains,
Abu Jahl, led Meccan opposition to the Muslims and organized a boycott of Muhammad's clan, the Banu Hashim, in circa 616–618. ==Genealogical tree of key members==