Shortly after a TKO victory over
Steve Carl to become the
Titan Fighting Championships Welterweight Champion, and push his record to 9–0, Muhammad signed with the
UFC in 2016.
Ultimate Fighting Championship On July 7, 2016, at
UFC Fight Night 90, Muhammad made his UFC debut, as a short-notice replacement, against
Alan Jouban. He lost the fight via unanimous decision. Both participants were awarded
Fight of the Night bonuses for their performances. Muhammad next faced
Augusto Montaño on September 17, 2016, at
UFC Fight Night 94. He won the fight via TKO in the third round. Muhammad was expected to face
Lyman Good on November 12, 2016, at
UFC 205. However, on October 24, Good was pulled from the card after being notified by
USADA of a potential anti-doping violation stemming from an out-of-competition drug test sample collected ten days earlier. He was replaced by
Vicente Luque. Muhammad lost the fight via knockout in the first round. Muhammad was a short notice replacement and stepped in to face
Randy Brown on February 11, 2017, at
UFC 208. He won the fight by unanimous decision. Muhammad faced
Jordan Mein on July 8, 2017, at
UFC 213. He won the fight by unanimous decision. Muhammad was expected to face
Jesse Taylor on November 19, 2017, at
UFC Fight Night: Werdum vs. Tybura. However, on September 13, it was announced that Taylor was pulled from the card after being notified by
USADA of a potential doping violation stemming from an out-of-competition drug test conducted on August 22. However, Price was removed from the bout on May 22 for undisclosed reasons and replaced by promotional newcomer
Chance Rencountre. Muhammad won the fight via unanimous decision. Muhammad was scheduled to meet
Elizeu Zaleski dos Santos on September 22, 2018, at
UFC Fight Night 137. However, on September 14, 2018, Muhammad was pulled from the bout and he was replaced by newcomer Luigi Vendramini. Muhammad faced
Geoff Neal on January 19, 2019, at
UFC Fight Night 143. He lost the fight by unanimous decision. Muhammad faced
Curtis Millender on April 13, 2019, at
UFC 236. He won the fight by unanimous decision. Muhammad faced
Takashi Sato on September 7, 2019, at
UFC 242. He won the fight via a rear-naked choke submission in the third round. This win earned Muhammad his first
Performance of the Night award. Muhammad was expected to face
Lyman Good on April 18, 2020, at
UFC 249. However on April 4, Good pulled out due to
COVID-19 infection. The bout was rebooked and eventually took place on June 20, 2020, at
UFC on ESPN: Blaydes vs. Volkov. He won the fight via unanimous decision. Muhammad was expected to face
Sean Brady on December 19, 2020, at
UFC Fight Night 183. However in late October, Brady had a broken nose and had to pull out of their bout, and he was replaced by
Dhiego Lima. Subsequently, Muhammed was diagnosed with
COVID-19 during the week leading up to the event and the bout was scrapped from the card and the bout was rescheduled to February 13, 2021, at
UFC 258 Muhammad won the fight via unanimous decision. Muhammad faced
Leon Edwards on March 13, 2021, at
UFC Fight Night 187. During the second round, Edwards poked Muhammad in the eye rendering him unable to continue. The fight was declared a no contest. Muhammad faced
Demian Maia on June 12, 2021, at
UFC 263. Muhammad won the fight via unanimous decision. Muhammad faced
Stephen Thompson on December 18, 2021, at
UFC Fight Night: Lewis vs. Daukaus. He won the bout via unanimous decision. Muhammad faced
Vicente Luque in a rematch on April 16, 2022, at
UFC on ESPN 34. He won the fight via unanimous decision. Muhammad faced
Sean Brady on October 22, 2022, at
UFC 280. He won the bout via TKO stoppage at the end of the second round.
UFC Hall of Famer and former
UFC Lightweight Champion Khabib Nurmagomedov was one of his cornermen for this fight. He received his second
Performance of the Night bonus. Muhammad faced
Gilbert Burns on May 6, 2023, at
UFC 288. Muhammad won by unanimous decision.
UFC Welterweight Champion Muhammad faced
Leon Edwards in a rematch, for the
UFC Welterweight Championship on July 27, 2024, at
UFC 304. He won the fight and the title by unanimous decision. Muhammad was scheduled to make his first
UFC Welterweight Championship defense against undefeated contender
Shavkat Rakhmonov on December 7, 2024, at
UFC 310. However, due to a bone infection in his foot, Muhammad was forced to withdraw, delaying his first title defense. Despite his absence from the card, Muhammad attended the event and attempted to enter the Octagon for a post-fight face-off with Rakhmonov. However, in an instance of mistaken identity, arena security—unaware of his status as the reigning champion—blocked his entry and treated him as an over-excited fan. The awkward delay lasted until commentator
Joe Rogan took to the microphone to clarify, "He's the champion, let him in!" The incident became a subject of ridicule on social media, most notably from
Conor McGregor, who mockingly questioned the champion's level of fame. In February 2025, with Rakhmonov unable to compete due to an injury, Muhammad was scheduled to instead defend his title against
Jack Della Maddalena on May 10, 2025, at
UFC 315. He lost the fight and the title by unanimous decision. This fight earned him another
Fight of the Night award.
Post-championship Muhammad faced
Ian Machado Garry on November 22, 2025, at
UFC Fight Night 265. He lost the fight by unanimous decision. Muhammad is scheduled to face
Gabriel Bonfim at
UFC Fight Night 278 on June 6, 2026. ==Professional grappling career==