The area was populated by
Finnic peoples and then colonized by the
Novgorod Republic. The principal direction of the colonization was along the Sukhona, which at the time was the main waterway connecting central Russia with the White Sea. In the 15th century, the area gradually fell under the control of the
Grand Duchy of Moscow, after being split into insignificant principalities such as the
Principality of Avnega. The
selo of Shuyskoye was first mentioned in 1555 as Shuysky Nizovets and achieved prominence in the 17th century as a settlement of shipbuilders, delivering ships mainly to Vologda. In 1370,
Avnezhsky Monastery was established on the bank of the Sukhona at the mouth of the
Avnega River. In the course of the
administrative reform carried out in 1708 by
Peter the Great, the area was included into
Archangelgorod Governorate. In 1780, the governorate was abolished and transformed into
Vologda Viceroyalty. The viceroyalty was abolished in 1796, and the part of it which included the area of what is now Mezhdurechensky District was made into
Vologda Governorate. The area was split between
Totemsky,
Gryazovetsky, and
Vologodsky Uyezds. On July 15, 1929, several governorates, including Vologda Governorate, were merged into
Northern Krai, and the uyezds were abolished. Instead, Shuysky District with the administrative center in the
selo of Shuyskoye was established as a part of
Vologda Okrug. In 1931, Shuysky District was renamed Mezhdurechensky. In the following years, the first-level administrative division of Russia kept changing. In 1936, Northern Krai was transformed into
Northern Oblast. In 1937, Northern Oblast was split into Arkhangelsk Oblast and Vologda Oblast. Mezhdurechensky District remained in Vologda Oblast ever since. On July 15, 1929,
Tolshmensky District with the administrative center in the
selo of
Krasnoye was also established. On July 30, 1931, it was abolished and divided between Shuysky and Totemsky Districts. On January 25, 1935,
Biryakovsky District was established on the lands which previously belonged to Sokolsky and Mezhdurechensky Districts. The administrative center of the district became the
selo of
Biryakovo, currently in Sokolsky District. In 1959, it was abolished and split between Sokolsky and Mezhdurechensky Districts. ==Economy==