Atlanta United Vázquez signed with Major League Soccer expansion club
Atlanta United in December 2016 ahead of their
inaugural season. In his first two seasons with the club, under manager
Tata Martino, Vázquez was deployed as a
winger rather than his natural position of leading the line as a
striker. As a reserve, Vázquez made 21 appearances and scored one goal over those two seasons, culminating with Atlanta winning the MLS Cup title in
2018.
FC Cincinnati On November 19, 2019, Vázquez was selected by
Nashville SC in the
2019 MLS Expansion Draft. He was subsequently traded to
FC Cincinnati in exchange for $150,000 in Targeted Allocation Money. After mainly appearing as a substitute, Vázquez made his breakthrough in the
2022 season. He opened the season as the undisputed starter for the first time in his career. The following week, Vázquez registered another brace and added an assist in a 3–1 win over
Inter Miami. In the 24th minute, he rose to win a cross, beating the defenders and goalkeeper to the ball. His insurance goal, another header, sealed back-to-back victories for Cincinnati. Brandon Vazquez has already set the record for the most goals in a single season in FC Cincinnati history. On August 3, Vázquez was selected for the
2022 MLS All-Star game as a replacement for striker
Valentín Castellanos who was loaned by
NYCFC to
LaLiga side
Girona FC after making the original 2022 roster. Vázquez became the second FC Cincinnati player to ever be selected for an MLS All-Star roster, after
attacking-midfielder teammate
Luciano Acosta had already been chosen for the 2022 matchup against
Liga MX All-Stars.
Monterrey On January 10, 2024, Vázquez joined
Liga MX club
Monterrey on a four-year deal. The transfer fee was reported to be between $6 million and $10 million. Vázquez scored five goals in
MLS, as well as four goals in the
U.S. Open Cup, in 2025. He sustained a torn
anterior cruciate ligament in the U.S. Open Cup quarterfinal against the
San Jose Earthquakes on July 8, ending his season and causing him to miss the beginning of the 2026 season as well. == International career ==